Anti-Growth hormone receptor/GHR Antibody Picoband®

Product Name

Anti-Growth hormone receptor/GHR Antibody Picoband®

View all Growth Hormone R Antibodies

SKU/Catalog Number

PA1726

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Growth hormone receptor/GHR Antibody catalog # PA1726. Tested in WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Growth hormone receptor/GHR Antibody Picoband® (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1726)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of mouse Growth hormone receptor, identical to the related rat sequence.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA1726 is reactive to Ghr in Mouse, Rat

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Observed Molecular Weight

72 kDa

Calculated molecular weight

72783 MW

Background of Growth Hormone R

The GHR locus to human chromosome 5p13.1-p12 and to mouse chromosome 15. Additionally, its gene has 9 exons that encode the receptor and several additional exons in the 5-prime untranslated region. The coding exons span at least 87 kb. GHR consists of an extracellular domain of 246 amino acids, a single transmembrane domain, and a cytoplasmic domain. Exons 3 to 7 encode the extracellular domain. There are 2 isoforms of GHR in humans, generated by retention or exclusion of exon 3 during splicing: a full-length isoform and an isoform that lacks exon 3 (d3GHR). Furthermore, the two isoforms of GHR are expressed in the placenta and appeared to be due to alternative splicing. In cirrhosis, there is a state of acquired GH resistance, as defined by high circulating GH levels with low IGF1 levels. Moreover, Mutations in the GHR gene have been demonstrated as the cause of Laron syndrome , also known as the growth hormone insensitivity syndrome (GHIS).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

PA1726 is guaranteed for WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Mouse, Rat

Positive Control

WB: Rat Liver Tissue, Rat Kidney Tissue, Rat Spleen Tissue, Rat Intestine Tissue, Mouse Spleen Tissue, Mouse Testis Tissue, Mouse Liver Tissue, Mouse Kidney Tissue, Mouse Intestine Tissue

Validation Images & Assay Conditions

Gene/Protein Information For Ghr (Source: Uniprot.org, NCBI)

Alternative Names

Growth hormone receptor;GH receptor;Somatotropin receptor;Growth hormone-binding protein;GH-binding protein;GHBP;Serum-binding protein;Ghr; GHR GHBP, GHIP growth hormone receptor growth hormone receptor|GH receptor|growth hormone binding protein|serum binding protein|somatotropin receptor

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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