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Product Info Summary
| SKU: | A03623-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-GRK6 Antibody
SKU/Catalog Number
A03623-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-GRK6 Antibody (Catalog # A03623-1). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
GRK6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Cite This Product
Anti-GRK6 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03623-1)
Host
Rabbit
Contents
GRK6 antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
GRK6 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human GRK6. The immunogen is located within the last 50 amino acids of GRK6.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
GRK6 antibody is human, mouse and rat reactive. Multiple isoforms of GRK6 are known to exist. This antibody is predicted to not cross-react with other members of the GRK protein family.
Reactive Species
A03623-1 is reactive to GRK6 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
65991 MW
Background of GRK6
The G protein–coupled receptor kinases (GRKs) are a versatile family of kinases that play a critical role in cancer metastasis through their regulation of G-protein coupled receptors (GPCRs) involved in growth factor mediated cell migration (1,2). Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state (1). GRK6 is one of 7 members of the GRK serine/threonine kinase subfamily, which has been shown to modulate the Wnt signaling pathway via phosphorylation of LRP6 (3,4), and the insulin-like growth factor signaling pathway (4). GRK6 may also play a role in immune system function (5).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A03623-1 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
GRK6 antibody can be used for detection of GRK6 by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of GRK6 in rat small intestine tissue lysate with GRK6 antibody at 1 μg/ml.
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Immunohistochemistry of GRK6 in human small intestine tissue with GRK6 antibody at 5 μg/mL.
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Immunofluorescence of GRK6 in human small intestine tissue with GRK6 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For GRK6 (Source: Uniprot.org, NCBI)
Gene Name
GRK6
Full Name
G protein-coupled receptor kinase 6
Weight
65991 MW
Superfamily
protein kinase superfamily
Alternative Names
GPRK6, GPRK6, G protein-coupled receptor kinase 6, G protein-coupled receptor kinase GRK6 GRK6 GPRK6 G protein-coupled receptor kinase 6 G protein-coupled receptor kinase 6
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on GRK6, check out the GRK6 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for GRK6: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-GRK6 Antibody (A03623-1)
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