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Product Info Summary
| SKU: | A06295-1 |
|---|---|
| Size: | 80 µl |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | Flow Cytometry, WB |
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Product info
Product Name
Anti-GPM6A Antibody (C-term)
SKU/Catalog Number
A06295-1
Size
80 µl
Description
Boster Bio Anti-GPM6A Antibody (C-term) (Catalog # A06295-1). Tested in WB, Flow Cytometry application(s). This antibody reacts with Human.
Storage & Handling
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Cite This Product
Anti-GPM6A Antibody (C-term) (Boster Biological Technology, Pleasanton CA, USA, Catalog # A06295-1)
Host
Rabbit
Contents
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Clonality
Polyclonal
Isotype
Rabbit IgG
Immunogen
This GPM6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 232-259 amino acids from the C-terminal region of human GPM6A.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A06295-1 is reactive to GPM6A in Human
Reconstitution
Calculated molecular weight
31210 Da
Background of GPM6A
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A06295-1 is guaranteed for Flow Cytometry, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:1000
FC: 1:10-1:50
Validation Images & Assay Conditions
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GPM6A Antibody (C-term) western blot analysis in SH-SY5Y cell line lysates (35ug/lane).This demonstrates the GPM6A antibody detected the GPM6A protein (arrow).
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GPM6A Antibody (C-term) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Protein Target Info & Infographic
Gene/Protein Information For GPM6A (Source: Uniprot.org, NCBI)
Gene Name
GPM6A
Full Name
Neuronal membrane glycoprotein M6-a
Weight
31210 Da
Superfamily
myelin proteolipid protein family
Alternative Names
Neuronal membrane glycoprotein M6-a, M6a, GPM6A, M6A GPM6A GPM6, M6A glycoprotein M6A neuronal membrane glycoprotein M6-a
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on GPM6A, check out the GPM6A Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for GPM6A: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-GPM6A Antibody (C-term) (A06295-1)
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