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Product Info Summary
| SKU: | A07481 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-GFR alpha 3 Gfra3 Antibody
View all GFR alpha-3/GDNF R alpha-3 Antibodies
SKU/Catalog Number
A07481
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-GFR alpha 3 Gfra3 Antibody (Catalog # A07481). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
GFR alpha 3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-GFR alpha 3 Gfra3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A07481)
Host
Rabbit
Contents
GFR alpha 3 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
GFR alpha 3 antibody was raised against a 14 amino acid peptide near the center of murine GFR alpha 3. The immunogen is located within the last 50 amino acids of GFR alpha 3.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
PHAP III has no cross-reaction to PHAP I and PHAP I2a.
Reactive Species
A07481 is reactive to GFRA3 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
44307 MW
Background of GFR alpha-3/GDNF R alpha-3
Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN) play essential roles in the control of vertebrate neuron survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphadidylinositol linked protein GFRα and Ret receptor tyrosine kinase GFRbeta. Following the findings of GFRα-1 and -2, a novel receptor in GFRα family was identified from human and mouse and designated GFRα-3. GFRα-3 binds persephin, thus, persephin, GFRα-3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A07481 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
GFR alpha 3 antibody can be used for detection of GFR alpha 3 expression by Western blot at 0.5 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 5 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in mouse samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of GFR alpha 3 in crude cell membrane fractions of mouse heart (H)
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Immunohistochemistry of GFR alpha 3 in mouse heart tissue with GFR alpha 3 antibody at 10 μg/mL.
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Immunofluorescence of GFR alpha 3 in mouse kidney tissue with GFR alpha 3 antibody at 5 μg/ml.
Green: GFR alpha 3 antibody (A07481)
Red: Phylloidin staining
Blue: DAPI staining
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Immunohistochemistry of GFR alpha 3 in mouse kidney tissue with GFR alpha 3 antibody at 5 μg/ml.
Protein Target Info & Infographic
Gene/Protein Information For GFRA3 (Source: Uniprot.org, NCBI)
Gene Name
GFRA3
Full Name
GDNF family receptor alpha-3
Weight
44307 MW
Superfamily
GDNFR family
Alternative Names
Y15110, GFRalpha3, GDNF family receptor alpha-3, GDNF receptor alpha-3 GFRA3 GDNFR3 GDNF family receptor alpha 3 GDNF family receptor alpha-3|GDNF receptor alpha-3|GDNFR-alpha-3|GFR-alpha-3|GPI-linked receptor|glial cell line-derived neurotrophic factor receptor alpha-3
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on GFRA3, check out the GFRA3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for GFRA3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-GFR alpha 3 Gfra3 Antibody (A07481)
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