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Product Info Summary
| SKU: | P03830 |
|---|---|
| Size: | 100 µl |
| Reactive Species: | Mouse, Rat |
| Host: | Rabbit |
| Application: | IHC, ICC, WB |
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Product info
Product Name
Anti-Phospho-GABAB R2 (Ser783) GABBR2 Antibody
SKU/Catalog Number
P03830
Size
100 µl
Form
Liquid
Description
Boster Bio Anti-Phospho-GABAB R2 (Ser783) GABBR2 Antibody (Catalog # P03830). Tested in WB, IHC, ICC applications. This antibody reacts with Mouse, Rat.
Storage & Handling
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C. After date of receipt, stable for at least 1 year at -20°C.
Cite This Product
Anti-Phospho-GABAB R2 (Ser783) GABBR2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # P03830)
Host
Rabbit
Contents
10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser783 of the R2 subunit of rat GABAB recerptor, conjugated to keyhole limpet hemocyanin (KLH). Immunogen species is Rat.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
No cross reactivity with other proteins.
Reactive Species
P03830 is reactive to GABBR2 in Mouse, Rat
Reconstitution
Observed Molecular Weight
52 kDa
Calculated molecular weight
105821 MW
Background of GABBR2
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABA-A and the GABA-B subtype of receptors. GABA-B receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. It has recently been demonstrated that AMPK binds directly to GABA-B receptors and phosphorylates Ser-783 in the cytoplasmic tail of the R2 subunit and that Ser-783 plays a critical role in enhancing neuronal survival after ischemia as phosphorylation of Ser-783 is evident in many brain regions and is increased dramatically after ischemic injury to the brain (Kuramoto et al., 2007).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
P03830 is guaranteed for IHC, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:1000
IHC: 1:500
ICC: 1:500
Validation Images & Assay Conditions
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Western blot of rat synaptic membrane lysate showing specific immunolabeling of the ~102 kDa GABAB R2 protein phosphorylated at Ser783 in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is completely eliminated by blot treatment with lambda phosphatase (gamma-Ptase, 1200 units for 30 min).
Protein Target Info & Infographic
Gene/Protein Information For GABBR2 (Source: Uniprot.org, NCBI)
Gene Name
GABBR2
Full Name
Gamma-aminobutyric acid type B receptor subunit 2
Weight
105821 MW
Superfamily
G-protein coupled receptor 3 family
Alternative Names
BcDNA:GH07312 antibody, CG6706 antibody, CT20836 antibody, D Gaba2 antibody, FLJ36928 antibody, G protein coupled receptor 51 antibody, G-protein coupled receptor 51 antibody, GAB B R2 antibody, GABA B R2 antibody, GABA B receptor 2 antibody, GABA-B receptor 2 antibody, GABA-B-R2 antibody, GABA-BR2 antibody, GABAB R2 antibody, GABABR 2 antibody, GABABR2 antibody, GABB R2 antibody, GABBR 2 antibody, Gabbr2 antibody, GABR2_HUMAN antibody, Gamma aminobutyric acid B receptor 2 antibody, Gamma aminobutyric acid GABA B receptor 2 antibody, Gamma aminobutyric acid type B receptor subunit 2 antibody, Gamma-aminobutyric acid type B receptor subunit 2 antibody, Gb 2 antibody, Gb2 antibody, GH07312 antibody, GPR 51 antibody, GPR51 antibody, GPRC 3B antibody, GPRC3B antibody, HG 20 antibody, HG20 antibody, HRIHFB2099 antibody, Metabotropic GABA B receptor subtype 2 antibody, OTTHUMP00000021776 antibody, OTTHUMP00000063797 antibody, R2 SUBUNIT antibody GABBR2 DEE59, EIEE59, GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099, NDPLHS gamma-aminobutyric acid type B receptor subunit 2 gamma-aminobutyric acid type B receptor subunit 2|G-protein coupled receptor 51|GABA-B receptor 2|GABA-B receptor, R2 subunit|GABA-B-R2|GABA-BR2|gamma-aminobutyric acid (GABA) B receptor, 2|gamma-aminobutyric acid B receptor 2|gb2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on GABBR2, check out the GABBR2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for GABBR2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Phospho-GABAB R2 (Ser783) GABBR2 Antibody (P03830)
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Customer Q&As
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3 Customer Q&As for Anti-Phospho-GABAB R2 (Ser783) GABBR2 Antibody
Question
We are currently using anti-Phospho-GABAB R2 (Ser783) antibody P03830 for mouse tissue, and we are satisfied with the IF results. The species of reactivity given in the datasheet says mouse, rat. Is it possible that the antibody can work on monkey tissues as well?
Verified Customer
Verified customer
Asked: 2019-05-01
Answer
The anti-Phospho-GABAB R2 (Ser783) antibody (P03830) has not been tested for cross reactivity specifically with monkey tissues, but there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in monkey you can get your next antibody for free. Please contact me if I can help you with anything.
Boster Scientific Support
Answered: 2019-05-01
Question
I see that the anti-Phospho-GABAB R2 (Ser783) antibody P03830 works with IF, what is the protocol used to produce the result images on the product page?
J. Thomas
Verified customer
Asked: 2018-01-16
Answer
You can find protocols for IF on the "support/technical resources" section of our navigation menu. If you have any further questions, please send an email to [email protected]
Boster Scientific Support
Answered: 2018-01-16
Question
you antibody to test anti-Phospho-GABAB R2 (Ser783) antibody P03830 on rat pubmed:15489334} for research purposes, then I may be interested in using anti-Phospho-GABAB R2 (Ser783) antibody P03830 for diagnostic purposes as well. Is the antibody suitable for diagnostic purposes?
H. Bhatt
Verified customer
Asked: 2016-01-07
Answer
The products we sell, including anti-Phospho-GABAB R2 (Ser783) antibody P03830, are only intended for research use. They would not be suitable for use in diagnostic work. If you have the means to develop a product into diagnostic use, and are interested in collaborating with us and develop our product into an IVD product, please contact us for more discussions.
Boster Scientific Support
Answered: 2016-01-07
