GABBR2 Antibodies

AND GABBR2 ELISA kits, GABBR2 Proteins

Many biological assays use antibodies to detect GABBR2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GABBR2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GABBR2 antibodies...

We validate the specificity of these antibodies to GABBR2 by testing them on tissues known to express GABBR2 positively and negatively. Browse below to find the GABBR2 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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GABBR2 Infographic by Boster Bio

All GABBR2 Products

Product

Figures

Specificity

Applications

Price

Anti-Phospho-GABAB R2 (Ser783) GABBR2 Antibody

3 Q&As

Mouse, Rat

IHC, ICC, WB

$465
Cat # P03830
100 µl

Anti-GABA B Receptor 2 Gabbr2 Antibody

Human, Mouse, Rat

Flow Cytometry, IHC, ICC, WB

$405
Cat # A03830-1
100ul

Anti-GABA B Receptor 2 Rabbit Monoclonal Antibody

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M03830-2
100 μl/vial

GABA B Receptor 2 (GABBR2) (NM_005458) Human Over-expression Lysate

Human

$960
Cat # LS009568
100 µg

GABBR2 Overview

Facts about Gamma-aminobutyric acid type B receptor subunit 2.

GABBR2 3D structure. Source: alphafold

Gamma-aminobutyric acid type B receptor subunit 2 (GABBR2)

Part of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054).
Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688).

Ligand binding causes a conformation change that activates signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016, PubMed:24305054). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9872744, PubMed:22660477).

Gene Information

Human
Gene Name:	GABBR2
Uniprot:	O75899
Entrez:	9568

Family

Belongs to:

G-protein coupled receptor 3 family

Alternative Names

GABA B Receptor Compounds

Molecular Weight

Mass (kDA):
105.821 kDA

Genomic Context


Human

Location:	9q22.33
Sequence:	9; NC_000009.12 (98288104..98708935, complement)

Tissue Specificity

Highly expressed in brain, especially in cerebral cortex, thalamus, hippocampus, frontal, occipital and temporal lobe, occipital pole and cerebellum, followed by corpus callosum, caudate nucleus, spinal cord, amygdala and medulla (PubMed:10087195, PubMed:10328880, PubMed:10727622, PubMed:9872744). Weakly expressed in heart, testis and skeletal muscle (PubMed:10087195, PubMed:10727622).

Subcellular Localizations

Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane. In contrast, GABBR2 does not depend on GABBR1 for transport to the cell membrane.

Diseases

Neurodevelopmental disorder with poor language and loss of hand skills (NDPLHS)

Interacting Proteins

GABBR1
NSF

PTMs

Disulfide bond

Glycoprotein

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GABBR2

References

PMID: 9872316 by White J.H., et al. Heterodimerization is required for the formation of a functional GABA(B) receptor.

PMID: 10087195 by Ng G.Y.K., et al. Cloning of a novel G-protein-coupled receptor GPR 51 resembling GABAB receptors expressed predominantly in nervous tissues and mapped proximal to the hereditary sensory neuropathy type 1 locus on chromosome 9.