Anti-GABA Transporter 1/GAT 1/SLC6A1 Antibody Picoband®

Product Name

Anti-GABA Transporter 1/GAT 1/SLC6A1 Antibody Picoband®

View all GAT-1/SLC6A1 Antibodies

SKU/Catalog Number

PA1721

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-GABA Transporter 1/GAT 1/SLC6A1 Antibody catalog # PA1721. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-GABA Transporter 1/GAT 1/SLC6A1 Antibody Picoband® (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1721)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human GABA Transporter 1, identical to the related rat and mouse sequences.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA1721 is reactive to SLC6A1 in Human, Mouse, Rat

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Observed Molecular Weight

29 kDa

Calculated molecular weight

67074 MW

Background of GAT-1/SLC6A1

GABA transporter 1 (GAT1), also known as sodium- and chloride-dependent GABA transporter 1, is a protein that in humans is encoded by the SLC6A1 gene. GABA Transporter 1 uses Na+ and Cl- to create a gradient, which removes or adds GABA to extracellular spaces in the cerebrum and cerebellum. The stoichiometry for GABA Transporter 1 is 2 Na+: 1 Cl-: 1 GABA. The activity of GAT1 is largely dependent on the presence of Na+, while Cl- assists by increasing the ability for GAT-1 to uptake GABA.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

PA1721 is guaranteed for IHC, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Rat, Human, Mouse , By Heat
Western blot, 0.1-0.5μg/ml, Mouse, Rat, Human

Positive Control

WB: Rat Brain Tissue, Mouse Brain Tissue,
IHC: Rat Brain Tissue

Validation Images & Assay Conditions

Gene/Protein Information For SLC6A1 (Source: Uniprot.org, NCBI)

Alternative Names

Sodium- and chloride-dependent GABA transporter 1;GAT-1;Solute carrier family 6 member 1;SLC6A1;GABATR, GABT1, GAT1; SLC6A1 GABATHG, GABATR, GAT1, MAE solute carrier family 6 member 1 sodium- and chloride-dependent GABA transporter 1|GABA transporter 1|solute carrier family 6 (neurotransmitter transporter), member 1|solute carrier family 6 (neurotransmitter transporter, GABA), member 1

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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