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Product Info Summary
| SKU: | A07114 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-G-protein coupled receptor 3 GPR3 Antibody
SKU/Catalog Number
A07114
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-G-protein coupled receptor 3 GPR3 Antibody (Catalog # A07114). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
GPR3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-G-protein coupled receptor 3 GPR3 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A07114)
Host
Rabbit
Contents
GPR3 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
GPR3 antibody was raised against a 13 amino acid synthetic peptide from near the carboxy terminus of human GPR3. The immunogen is located within the last 50 amino acids of GPR3.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
GBP5 antibody is predicted to not cross-react with other GBP family members.
Reactive Species
A07114 is reactive to GPR3 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
35010 MW
Background of GPR3
GPR3, also known as ACCA, is a G-protein coupled receptor that constitutively activates adenylate cyclase and is highly expressed in the central nervous system. Overexpression of GPR3 stimulates the production of amyloid-beta peptide (Abeta), the deposition of which is one of the pathological hallmarks of Alzheimer 's disease (AD), while the ablation of GPR3 prevented the accumulation of Abeta in vitro and in an AD mouse model. This is of particular interest because of the proximity of a reported candidate Alzheimer 's disease (AD) locus, suggesting that GPR3 may be a potential therapeutic target for the treatment of AD. GPR3 has also been shown to block the proliferation of cerebellar granule cell precursors (GCP) during postnatal development by inhibiting the Shh-induced proliferation of GCP, indicating that GPR3 activation may represent one of the signals that triggers the postnatal cell cycle exit and terminal differentiation of GPCs.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A07114 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
GPR3 antibody can be used for detection of GPR3 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in mouse samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of GPR3 in EL4 cell lysate with GPR3 antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of GPR3 in human spleen tissue with GPR3 antibody at 2.5 μg/mL.
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Immunofluorescence of GPR3 in Human Spleen cells with GPR3 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For GPR3 (Source: Uniprot.org, NCBI)
Gene Name
GPR3
Full Name
G-protein coupled receptor 3
Weight
35010 MW
Superfamily
G-protein coupled receptor 1 family
Alternative Names
ACCA, ACCA, G-protein coupled receptor 3, ACCA orphan receptor GPR3 ACCA G protein-coupled receptor 3 G-protein coupled receptor 3|ACCA orphan receptor|adenylate cyclase constitutive activator
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on GPR3, check out the GPR3 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for GPR3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-G-protein coupled receptor 3 GPR3 Antibody (A07114)
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