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Product Info Summary
| SKU: | A12236 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IHC-P, WB |
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Product info
Product Name
Anti-FRMPD2 Antibody
SKU/Catalog Number
A12236
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-FRMPD2 Antibody (Catalog # A12236). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
FRMPD2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-FRMPD2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A12236)
Host
Rabbit
Contents
FRMPD2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
FRMPD2 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human FRMPD2. The immunogen is located within amino acids 80 - 130 of FRMPD2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
UHRF1BP1 antibody is predicted to not cross-react with UHRF1BP1L
Reactive Species
A12236 is reactive to FRMPD2 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
144282 MW
Background of FRMPD2
The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one, erzin, radixin, moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain. FRMPD2 also contains an N-terminal KIND domain and three PDZ domains and is structurally similar to the protein tyrosine phosphatase PTP-BL. FRMPD2 is localized in a polarized fashion in epithelial cells at the basolateral membrane and partially co-localizes with the tight-junction marker protein Zonula-occuldens-1. Suppression of FRMPD2 expression via RNAi in Caco-2 cells results in an impairment of tight junction formation, indicating that FRMPD2 plays a major role in tight junction formation. Other experiments indicate that FRMPD2 is a binding partner to several catenin family members and recruitment of FRMPD2 to cell-cell contacts is dependent on E-cadherin-mediated cell-cell adhesion.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A12236 is guaranteed for ELISA, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
FRMPD2 antibody can be used for detection of FRMPD2 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in rat samples and Immunohistochemistry in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of FRMPD2 in rat kidney tissue lysate with FRMPD2 antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of FRMPD2 in mouse kidney tissue with FRMPD2 antibody at 5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For FRMPD2 (Source: Uniprot.org, NCBI)
Gene Name
FRMPD2
Full Name
FERM and PDZ domain-containing protein 2
Weight
144282 MW
Alternative Names
PDZK4, PDZD5C, PDZK5C, PDZK4, FERM and PDZ domain-containing protein 2, PDZ domain-containing protein 4 FRMPD2 PDZD5C, PDZK4, PDZK5C FERM and PDZ domain containing 2 FERM and PDZ domain-containing protein 2|PDZ domain containing 5C|PDZ domain-containing protein 4
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on FRMPD2, check out the FRMPD2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for FRMPD2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-FRMPD2 Antibody (A12236)
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No publications found for A12236
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