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Product Info Summary
| SKU: | A01819 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-Forkhead box protein O4 FOXO4 Antibody
SKU/Catalog Number
A01819
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Forkhead box protein O4 FOXO4 Antibody (Catalog # A01819). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
FOXO4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Forkhead box protein O4 FOXO4 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01819)
Host
Rabbit
Contents
FOXO4 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
FOXO4 antibody was raised against a 16 amino acid synthetic peptide near the amino terminus of human FOXO4. The immunogen is located within amino acids 30 - 80 of FOXO4.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
It has no cross response to IKKa, IKKb, or IKKy.
Reactive Species
A01819 is reactive to FOXO4 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
53684 MW
Background of FOXO4
FOXO4 is a ubiquitously expressed protein member of a subfamily of the forkhead homeotic gene family of transcription factors and shuttles between the cytoplasm and nucleus. FOXO transcription factors are key players of cell fate decisions, metabolism, stress resistance, tumor suppression and are regulated by growth factors, oxidative stress or nutrient deprivation. In the absence of PI3K/AKT activation, FOXO4 localizes in the nucleus where it functions as a transcription factor. FOXO4 can also be phosphorylated by JNK following induction of reactive oxygen species (ROS), resulting in transcriptional activation and the induction of a negative feedback mechanism to counteract the ROS. It is through this mechanism that FOXO4 is thought to sensitize cancer cells to doxorubicin-mediated toxicity.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A01819 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
FOXO4 antibody can be used for detection of FOXO4 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunocytochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of FOXO4 in HeLa cell lysate with FOXO4 antibody at (A) 0.5 and (B) 1 μg/mL.
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Immunocytochemistry of FOXO4 in HeLa cells with FOXO4 antibody at 10 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For FOXO4 (Source: Uniprot.org, NCBI)
Gene Name
FOXO4
Full Name
Forkhead box protein O4
Weight
53684 MW
Alternative Names
AFX, AFX1, MLLT7, AFX, Forkhead box protein O4, Fork head domain transcription factor AFX1 FOXO4 AFX, AFX1, MLLT7 forkhead box O4 forkhead box protein O4|fork head domain transcription factor AFX1|myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on FOXO4, check out the FOXO4 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for FOXO4: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Forkhead box protein O4 FOXO4 Antibody (A01819)
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No publications found for A01819
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