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Product Info Summary
| SKU: | A00388-1 |
|---|---|
| Size: | 100 µl |
| Reactive Species: | Human, Mouse |
| Host: | Rabbit |
| Application: | IHC, WB |
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Product info
Product Name
Anti-ERCC1 Antibody
SKU/Catalog Number
A00388-1
Size
100 µl
Form
Liquid
Description
Boster Bio Anti-ERCC1 Antibody (Catalog # A00388-1). Tested in WB, IHC applications. This antibody reacts with Human, Mouse.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-ERCC1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00388-1)
Host
Rabbit
Contents
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human ERCC1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Does not cross-react with eNOS or nNOS.
Reactive Species
A00388-1 is reactive to ERCC1 in Human, Mouse
Reconstitution
Calculated molecular weight
32562 MW
Background of ERCC1
Isoform 1:Non-catalytic component of a structure-specific DNA repair endonuclease responsible for the 5'-incision during DNA repair. Responsible, in conjunction with SLX4, for the first step in the repair of interstrand cross-links (ICL). Participates in the processing of anaphase bridge-generating DNA structures, which consist in incompletely processed DNA lesions arising during S or G2 phase, and can result in cytokinesis failure. Also required for homology-directed repair (HDR) of DNA double-strand breaks, in conjunction with SLX4.
Kan-Tai Hsia, Development, Jan 2003; 130: 369.
Jim Selfridge, Nucleic Acids Res., Nov 2001; 29: 4541 - 4550.
Cha-Kyung Youn, Cancer Res., Jul 2004; 64: 4849 - 4857.
Teresa A. Motycka, J. Biol. Chem., Apr 2004; 279: 13634 - 13639.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A00388-1 is guaranteed for IHC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Validation Images & Assay Conditions
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Western blot analysis of extracts from NIH/3T3 cells, using ERCC1 antibody A00388-1.
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Western blot analysis of extracts from Hela cells (Lane 2), using ERCC1 antiobdy A00388-1. The lane on the left is treated with synthesized peptide.
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Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using ERCC1 antibody A00388-1.
Protein Target Info & Infographic
Gene/Protein Information For ERCC1 (Source: Uniprot.org, NCBI)
Gene Name
ERCC1
Full Name
DNA excision repair protein ERCC-1
Weight
32562 MW
Superfamily
ERCC1/RAD10/SWI10 family
Alternative Names
DNA excision repair protein ERCC-1;ERCC1; ERCC1 COFS4, RAD10, UV20 ERCC excision repair 1, endonuclease non-catalytic subunit DNA excision repair protein ERCC-1|excision repair cross-complementation group 1|excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on ERCC1, check out the ERCC1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for ERCC1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-ERCC1 Antibody (A00388-1)
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No publications found for A00388-1
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