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Key=sku, value=PB9863
Key=has_options, value=1
Key=required_options, value=1
Key=created_at, value=2016-02-26 13:47:39
Key=updated_at, value=2024-09-26 00:47:00
Key=mst_search_weight, value=0
Key=status, value=Enabled
Key=name, value=Anti-EGFR Antibody Picoband®
Key=cj_search_index
Key=publication_count, value=3
Key=qty_in_warehouses
Key=is_recurring, value=No
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Key=template, value=antibodies
Key=host, value=Rabbit
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Key=yoast_keyword_score, value=-1358
Key=yoast_content_score, value=30
Key=badge, value=free-antibody-validation
Key=price, value=370.0000
Key=weight, value=1.0000
Key=meta_title, value=Anti-EGFR Antibody Picoband | Bosterbio PB9863
Key=image, value=/p/b/pb9863-egfr-primary-antibodies-wb-testing-1.jpg
Key=small_image, value=/p/b/pb9863-egfr-primary-antibodies-wb-testing-1.jpg
Key=thumbnail, value=/p/b/pb9863-egfr-primary-antibodies-wb-testing-1.jpg
Key=url_key, value=anti-egf-picoband-trade-antibody-pb9863-boster
Key=url_path, value=anti-egf-picoband-trade-antibody-pb9863-boster
Key=options_container, value=Product Info Column
Key=image_label, value=Figure 1. Western blot analysis of EGFR using anti-EGFR antibody (PB9863).
Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 30 ug of sample
Key=small_image_label, value=Figure 1. Western blot analysis of EGFR using anti-EGFR antibody (PB9863).
Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 30 ug of sample
Key=thumbnail_label, value=Figure 1. Western blot analysis of EGFR using anti-EGFR antibody (PB9863).
Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 30 ug of sample
Key=msrp_display_actual_price_type, value=
Key=gift_message_available, value=No
Key=size, value=100 μg/vial
Key=protein_name, value=Epidermal growth factor receptor
Key=gene_full_name, value=Epidermal growth factor receptor
Key=uniprot_id, value=Q01279
Key=reconstitution, value=Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Key=sensitivity
Key=applications, value=WB
Key=reactivity, value=Human, Mouse
Key=form, value=Lyophilized
Key=concentration, value=Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Key=cross_reactivity, value=No cross-reactivity with other proteins.
Key=recommended_detection_systems, value=Boster recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (EK1002) for Western blot.
Key=predicted_reactivity
Key=source_company, value=Boster PB9863
Key=isotype, value=Rabbit IgG
Key=molecular_weight, value=134853 MW
Key=sample_size_available, value=30ug for $99, contact us for details
Key=related_product_skus, value=B0001-5,AR1156,AR0146
Key=product_category, value=Primary Antibodies
Key=research_category, value=Cancer, Growth Factors/Hormones, Oncoproteins, Oncoproteins/Suppressors, Protein Phosphorylation, Receptor Tyrosine Kinases, Signal Transduction, Tumor Biomarkers, Tyrosine Kinases
Key=clonality, value=Polyclonal
Key=swatch_image, value=/antibody/ek0327-2-ELISA-human-egfr-picokine-elisa-kit.jpg
Key=rating_value, value=100
Key=review_count, value=19
Key=phospho_site
Key=mp_exclude_sitemap, value=Yes
Key=yoast_focus_keyword, value=Cathepsin D/CTSD Antibody
Key=yoast_facebook_image, value=/p/b/pb9800-cd19-primary-antibodies-wb-testing-1.jpg
Key=yoast_twitter_image, value=/p/b/pb9800-cd19-primary-antibodies-wb-testing-1.jpg
Key=cj_related_products, value=Drug Resistance:DZ14469-1^Glioblastoma:PA2133|EK1555|EK1556^Non-small Cell Lung Carcinoma:PROTQ8N6Y1^Transport:A12836
Key=description, value=Boster Bio Anti-EGFR Antibody Picoband® catalog # PB9863. Tested in WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Key=short_description, value=Boster Bio Anti-EGFR Antibody Picoband® catalog # PB9863. Tested in WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
Key=meta_keyword, value=Anti-EGFR Antibody Picoband®
Key=contents, value=Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Key=background, value=The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. It is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). EGFR exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor α (TGFα). EGFR and its ligands are cell signaling molecules involved in diverse cellular functions, including cell proliferation, differentiation, motility, and survival, and in tissue development. Mutations that lead to EGFR overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including lung cancer and glioblastoma multiforme. In this latter case a more or less specific mutation of EGFR, called EGFRvIII is often observed.
Key=gene_name, value=Egfr
Key=synonyms, value=Epidermal growth factor receptor;2.7.10.1;Egfr;
Key=application_details, value=Western blot, 0.1-0.5μg/ml, Human, Mouse

Key=subcellular_localization, value= Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Golgi apparatus membrane ; Single-pass type I membrane protein . Nucleus membrane ; Single-pass type I membrane protein . Endosome. Endosome membrane. Nucleus . In response to EGF, translocated from the cell membrane to the nucleus via Golgi and ER. Endocytosed upon activation by ligand. Colocalized with GPER1 in the nucleus of estrogen agonist-induced cancer-associated fibroblasts (CAF) (By similarity). .
Key=tissue_specificity, value= Expressed in kidney, salivary gland, cerebrum and prostate. .
Key=application_notes, value=Tested Species: In-house tested species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.
Key=competitor_equivalent_skus, value=sc 101|sc 31155|sc 53274|sc 80543|sc 365829|sc 31156|sc 31157|sc 373746|sc 120|sc 71032|sc 71033|sc 71035|sc 71034|sc 15827|sc 15828|sc 33746|sc 377073|sc 374607|sc 377229|sc 03|sc 367974|sc 514994|sc 514995
Key=immunogen, value=E. coli-derived mouse EGFR recombinant protein (Position: L25-L249). Mouse EGFR shares 88% amino acid (aa) sequence identity with human EGFR.
Key=purification, value=Immunogen affinity purified.
Key=storage, value=Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Key=custom_attribute_1, value=175 kDa
Key=custom_attribute_2, value=WB: human A431 whole cell, human A549 whole cell, human U87 whole cell, mouse liver tissue
Key=custom_attribute_3, value=PB0905
Key=protein_function, value= Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS- RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. .
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