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Key=entity_id, value=24365
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Key=sku, value=A05653
Key=has_options, value=1
Key=required_options, value=1
Key=created_at, value=2017-01-17 05:22:49
Key=updated_at, value=2024-09-26 00:49:36
Key=mst_search_weight, value=0
Key=status, value=Enabled
Key=name, value=Anti-EFEMP2 Antibody
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Key=is_recurring, value=No
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Key=template, value=antibodies
Key=host, value=Rabbit
Key=googleshopping_exclude, value=No
Key=yoast_keyword_score, value=-1217
Key=yoast_content_score, value=90
Key=price, value=360.0000
Key=weight, value=1.0000
Key=meta_title, value=Anti-EFEMP2 Antibody A05653
Key=meta_description, value=Boster Bio Anti-EFEMP2 Antibody (Catalog # A05653). Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse. Supplied as 100μl in Liquid form antibody.
Key=image, value=/a/0/a05653-immunohistochemistry-analysis-1.jpg
Key=small_image, value=/a/0/a05653-immunohistochemistry-analysis-1.jpg
Key=thumbnail, value=/a/0/a05653-immunohistochemistry-analysis-1.jpg
Key=url_key, value=anti-efemp2-antibody-a05653-boster
Key=url_path, value=anti-efemp2-antibody-a05653-boster
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Key=image_label, value=Immunohistochemistry analysis of paraffin-embedded human placenta tissue using EFEMP2 antibody A05653.
Key=small_image_label, value=Immunohistochemistry analysis of paraffin-embedded human placenta tissue using EFEMP2 antibody A05653.
Key=thumbnail_label, value=Immunohistochemistry analysis of paraffin-embedded human placenta tissue using EFEMP2 antibody A05653.
Key=msrp_display_actual_price_type, value=
Key=gift_message_available, value=No
Key=size, value=100 µl
Key=protein_name, value=mRNA decay activator protein ZFP36L1
Key=gene_full_name, value=EGF-containing fibulin-like extracellular matrix protein 2
Key=uniprot_id, value=O95967
Key=applications, value=IF, IHC, WB
Key=reactivity, value=Human, Mouse
Key=form, value=Liquid
Key=concentration, value=1 mg/ml
Key=predicted_reactivity, value=Boar, Bovine, Canine, Golden Hamster
Key=source_company, value=SabBiotech 34666; Cost: 159.5
Key=isotype, value=IgG
Key=molecular_weight, value=49405 MW
Key=sample_size_available, value=5ul, free with shipping charge
Key=related_product_skus, value=A30669
Key=product_category, value=Primary Antibodies
Key=research_category, value=Cytoskeleton/ECM, ECM Proteins, Extracellular Matrix, Signal Transduction
Key=clonality, value=Polyclonal
Key=swatch_image, value=/a/0/a05471-cart-primary-antibodies-wb-testing-1.jpg
Key=rating_value, value=100
Key=review_count, value=4
Key=mp_exclude_sitemap, value=No
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Key=cj_related_products, value=Aneurysm:EK0466|PB9668^Keratinocyte Differentiation:EKC1463^Oligohydramnios:PB10044|M02898-1|M06530
Key=description, value=Boster Bio Anti-EFEMP2 Antibody (Catalog # A05653). Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse.
Key=short_description, value=Boster Bio Anti-EFEMP2 Antibody (Catalog # A05653). Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse.
Key=meta_keyword, value=Anti-EFEMP2 Antibody
Key=contents, value=Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Key=background, value=A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. The protein encoded by this gene contains four EGF2 domains and six calcium-binding EGF2 domains. This gene is necessary for elastic fiber formation and connective tissue development. Defects in this gene are cause of an autosomal recessive cutis laxa syndrome. Alternatively spliced transcript variants have been identified for this gene.

Giltay R., Matrix Biol. 18:469-480(1999).
Zemel R., Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
Katsanis N., Hum. Genet. 106:66-72(2000).
Key=gene_name, value=EFEMP2
Key=synonyms, value=EGF-containing fibulin-like extracellular matrix protein 2;Fibulin-4;FIBL-4;Protein UPH1;EFEMP2;FBLN4;UNQ200/PRO226;
Key=application_details, value=Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:500
Key=subcellular_localization, value= Secreted.
Key=tissue_specificity, value=Expressed mainly in the basal epidermal layer, weakly in the suprabasal epidermal layers (PubMed:27182009). Expressed in epidermal keratinocytes (at protein level) (PubMed:27182009). Expressed in osteoblasts (PubMed:15465005).
Key=competitor_equivalent_skus, value=sc 98443|sc 79241|sc 79240
Key=immunogen, value=Synthesized peptide derived from internal of human EFEMP2.
Key=purification, value=The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Key=storage, value=Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Key=custom_attribute_1, value=111 kDa
Key=protein_function, value=Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly (A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258). Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:15687258, PubMed:18326031, PubMed:25106868). Induces also the degradation of ARE-containing mRNAs even in absence of poly (A) tail (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12198173, PubMed:15538381, PubMed:15467755, PubMed:17030608, PubMed:19179481, PubMed:20702587, PubMed:24700863, PubMed:25106868, PubMed:25014217, PubMed:26542173). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE- mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (PubMed:26542173). Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs), such as NANOG, through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway, and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217). In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity- joining (VDJ) recombination and functional immune cell formation (By similarity). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity). Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly (A)) signal in endothelial cells (PubMed:21832157). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811). Plays a role in vasculogenesis and endocardial development (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role in myoblast cell differentiation (By similarity).
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