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Product Info Summary
| SKU: | A04130 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-E3 SUMO-protein ligase PIAS2 PIAS2 Antibody
SKU/Catalog Number
A04130
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-E3 SUMO-protein ligase PIAS2 PIAS2 Antibody (Catalog # A04130). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
PIAS2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-E3 SUMO-protein ligase PIAS2 PIAS2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04130)
Host
Rabbit
Contents
PIAS2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
PIAS2 antibody was raised against a 18 amino acid synthetic peptide near the amino terminus of human PIAS2. The immunogen is located within amino acids 110 - 160 of PIAS2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
OASL antibody is human, mouse and rat reactive.
Reactive Species
A04130 is reactive to PIAS2 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
68240 MW
Background of PIAS2
The PIAS (protein inhibitor of activated STAT) proteins play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS2. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS2 binds specifically to STAT4 following IL-12 stimulation and inhibits STAT4-mediated gene activation in human T cells. PIAS2 is a potent transcriptional activator of Bcl-2, but together with Bcl-6 can suppress the expression of Bcl-2.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A04130 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
PIAS2 antibody can be used for detection of PIAS2 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of PIAS2 in rat brain tissue lysate with PIAS2 antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of PIAS2 in rat brain tissue with PIAS2 antibody at 5 μg/mL.
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Immunofluorescence of PIAS2 in rat brain tissue with PIAS2 antibody at 20 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For PIAS2 (Source: Uniprot.org, NCBI)
Gene Name
PIAS2
Full Name
E3 SUMO-protein ligase PIAS2
Weight
68240 MW
Superfamily
PIAS family
Alternative Names
DIP, MIZ, MIZ1, SIZ2, ARIP3, PIASX, ZMIZ4, PIASX-BETA, PIASX-ALPHA, E3 SUMO-protein ligase PIAS2, Androgen receptor-interacting protein 3 PIAS2 ARIP3, DIP, MIZ1, PIASX, SIZ2, ZMIZ4 protein inhibitor of activated STAT 2 E3 SUMO-protein ligase PIAS2|DAB2-interacting protein|E3 SUMO-protein transferase PIAS2|androgen receptor-interacting protein 3|msx-interacting zinc finger protein|protein inhibitor of activated STAT X|zinc finger, MIZ-type containing 4
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on PIAS2, check out the PIAS2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for PIAS2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-E3 SUMO-protein ligase PIAS2 PIAS2 Antibody (A04130)
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