PIAS2 Antibodies

AND PIAS2 ELISA kits, PIAS2 Proteins

Many biological assays use antibodies to detect PIAS2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PIAS2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PIAS2 antibodies...

We validate the specificity of these antibodies to PIAS2 by testing them on tissues known to express PIAS2 positively and negatively. Browse below to find the PIAS2 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PIAS2 Infographic by Boster Bio

All PIAS2 Products

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Product

Figures

Specificity

Applications

Price

Anti-PIAS2 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A04130-3
100 μg/vial

Anti-E3 SUMO-protein ligase PIAS2 PIAS2 Antibody

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$449
Cat # A04130
0.1 mg

Anti-PIAS2 Mouse Monoclonal Antibody [Clone ID: OTI5B4]

Human, Mouse, Rat

$523
Cat # M04130
100 µl

Anti-PIAS2 Rabbit Monoclonal Antibody

Human, Mouse, Rat

IF, ICC, WB

$370
Cat # M04130-1
100 μl/vial

PIAS2 (NM_173206) Human Over-expression Lysate

Human

$628
Cat # LS009063
100 µg

PIAS2 Overview

Facts about E3 SUMO-protein ligase PIAS2.

PIAS2 3D structure. Source: alphafold

E3 SUMO-protein ligase PIAS2 (PIAS2)

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering element. Plays a critical role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway.

The impacts of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing.

Gene Information

Human
Gene Name:	PIAS2
Uniprot:	O75928
Entrez:	9063

Family

Belongs to:

PIAS family

Alternative Names

Androgen receptor-interacting protein 3; ARIP3; DAB2-interacting protein; DIP; E3 SUMO-protein ligase PIAS2; MGC102682; miz; MIZ1; Msx-interacting zinc finger protein; Msx-interacting-zinc finger; PIAS2; PIAS-NY protein; PIASx alpha; PIASX; PIASX-ALPHA; PIASX-BETA; Protein inhibitor of activated STAT x; protein inhibitor of activated STAT, 2; Protein inhibitor of activated STAT2; SIZ2; zinc finger, MIZ-type containing 4; ZMIZ4

Molecular Weight

Mass (kDA):
68.24 kDA

Genomic Context


Human

Location:	18q21.1
Sequence:	18; NC_000018.10 (46803218..46920167, complement)

Tissue Specificity

Mainly expressed in testis. Isoform 3 is expressed predominantly in adult testis, weakly in pancreas, embryonic testis and sperm, and at very low levels in other organs.

Subcellular Localizations

Nucleus speckle. Nucleus, PML body. Nucleus. Colocalizes at least partially with promyelocytic leukemia nuclear bodies (PML NBs) (PubMed:22406621). Colocalizes with SUMO1 in nuclear granules (By similarity).