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Product Info Summary
| SKU: | A09671-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IHC-P, WB |
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Product info
Product Name
Anti-DCLK2 Antibody
SKU/Catalog Number
A09671-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-DCLK2 Antibody (Catalog # A09671-1). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
DCLK2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-DCLK2 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09671-1)
Host
Rabbit
Contents
DCLK2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
DCLK2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human DCLK2. The immunogen is located within the last 50 amino acids of DCLK2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
VEZT antibody is human, mouse and rat reactive. Multiple isoforms are known to exist.
Reactive Species
A09671-1 is reactive to DCLK2 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
83606 MW
Background of DCAMKL2
DCLK2 is one of three doublecortin-like kinases similar to the Ca2+/calmodulin-dependent protein kinase (CaMK) family. DCLK2 mRNA, like that of the homologous DCLK1 and DCLK3, is highly expressed in adult brain, but only DCLK1 and DCLK2 transcripts are present in human fetal brain and the developing mouse embryo, suggesting that DCLK1 and DCLK2 may play roles in cortical development. The DCLK proteins are homologous to Doublecortin (DCX), a protein that is mutated in X-linked human lissencephaly. In mouse models where the DCX gene has been disrupted, DCLK1 expression increases slightly and appears to compensate for the loss of DCX, as mice mutant for both DCX and DCLK1 show a severe phenotype including perinatal lethality, disorganized neocortical layering, and profound hippocampal cytoarchitectural disorganization. Unlike DCLK1, DCLK2 expression does not change in DCX-null mice.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A09671-1 is guaranteed for ELISA, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
DCLK2 antibody can be used for detection of DCLK2 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in rat samples and Immunohistochemistry in rat samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of DCLK2 in rat brain tissue lysate with DCLK2 antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of DLCK2 in rat brain tissue with DLCK2 antibody at 5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For DCLK2 (Source: Uniprot.org, NCBI)
Gene Name
DCLK2
Full Name
Serine/threonine-protein kinase DCLK2
Weight
83606 MW
Superfamily
protein kinase superfamily
Alternative Names
CL2, DCK2, CLIK2, DCDC3, CLICK2, DCDC3B, DCAMKL2, CLICK-II, CaMK-like CREB regulatory kinase 2, CL2 Dclk2|6330415M09Rik, AU044875, CL2, CLICK2, Clic, Click-II, Dcamk, Dcamkl2|doublecortin-like kinase 2|serine/threonine-protein kinase DCLK2|caMK-like CREB regulatory kinase 2|doublecortin and CaM kinase-like 2|doublecortin-like and CAM kinase-like 2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on DCLK2, check out the DCLK2 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for DCLK2: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-DCLK2 Antibody (A09671-1)
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