Anti-Netrin receptor DCC DCC Antibody Picoband®

DCC antibody

Boster Bio Anti-Netrin receptor DCC DCC Antibody catalog # PA1910. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Product Info Summary

SKU: PA1910
Size: 100 μg/vial
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: IHC, WB

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Product Name

Anti-Netrin receptor DCC DCC Antibody Picoband®

View all DCC Antibodies

SKU/Catalog Number

PA1910

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Netrin receptor DCC DCC Antibody catalog # PA1910. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Netrin receptor DCC DCC Antibody Picoband® (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA1910)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human DCC, identical to the related mouse sequence, and different from the related rat sequence by one amino acid.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA1910 is reactive to DCC in Human, Mouse, Rat

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Observed Molecular Weight

56 kDa

Calculated molecular weight

158457 MW

Background of DCC

DCC (Deleted IN Colorectal Carcinoma) also known as CRC18 or CRCR1. The DCC gene encodes a functional receptor for netrin and mediates axon outgrowth and the steering response. Heterozygous loss-of-function mutations in DCC can result in congenital mirror movements. Alterations in DCC occur frequently in colorectal cancer. Studying a YAC contig containing the entire DCC coding region, they showed that the DCC gene spans approximately 1.4 Mb. Vogelstein (1995) stated that the precise location of the DCC gene was though to be 18q21.3. DCC is a receptor or a component of a receptor that mediates the effects of netrin-1 on commissural axons, and they complement genetic evidence for interactions between DCC and netrin homologs in C. DCC protein could be detected in varying abundance in all specimens of normal colonic mucosa analyzed as well as in all specimens of adenomatous polyps, colorectal carcinoma and colorectal liver metastases. DCC may function as a tumor-suppressor protein by inducing apoptosis in settings in which ligand is unavailable (for example, during metastasis or tumor growth beyond local blood supply) through functional caspase cascades by a mechanism that requires cleavage of DCC at asp1290. Stein et al. (2001) concluded that DCC plays a central role in netrin signaling of axon growth and guidance independent of A2B receptor activation.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

PA1910 is guaranteed for IHC, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat, By Heat
Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat

Positive Control

WB: Rat Brain Tissue, Mouse Brain Tissue, U87 Cell, SW620 Cell, COLO320 Cell, 293T Cell, HELA Cell
IHC: Human Intestinal Cancer Tissue

Validation Images & Assay Conditions

Gene/Protein Information For DCC (Source: Uniprot.org, NCBI)

Gene Name

DCC

Full Name

Netrin receptor DCC

Weight

158457 MW

Superfamily

immunoglobulin superfamily

Alternative Names

Netrin receptor DCC;Colorectal cancer suppressor;Immunoglobulin superfamily DCC subclass member 1;Tumor suppressor protein DCC;DCC;IGDCC1; DCC CRC18, CRCR1, HGPPS2, IGDCC1, MRMV1, NTN1R1 DCC netrin 1 receptor netrin receptor DCC|colorectal cancer suppressor|deleted in colorectal carcinoma|immunoglobulin superfamily DCC subclass member 1|putative colorectal tumor suppressor|tumor suppressor protein DCC

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on DCC, check out the DCC Infographic

DCC infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for DCC: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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1 Customer Q&As for Anti-Netrin receptor DCC DCC Antibody Picoband®

Question

We are currently using anti-DCC antibody PA1910 for mouse tissue, and we are satisfied with the WB results. The species of reactivity given in the datasheet says human, mouse, rat. Is it true that the antibody can work on canine tissues as well?

Verified Customer

Verified customer

Asked: 2019-12-31

Answer

The anti-DCC antibody (PA1910) has not been tested for cross reactivity specifically with canine tissues, though there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in canine you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2019-12-31

Order DetailsPrice
PA1910

100μg

$370
PA1910-10ug

10μg sample (liquid)

$99
PA1910-Biotin

100 μg Biotin conjugated

$570
PA1910-Cy3

100 μg Cy3 conjugated

$570
PA1910-Dylight488

100 μg Dylight488 conjugated

$570
PA1910-Dylight550

100 μg Dylight550 conjugated

$570
PA1910-Dylight594

100 μg Dylight594 conjugated

$570
PA1910-FITC

100 μg FITC conjugated

$570
PA1910-HRP

100 μg HRP conjugated

$570
PA1910-APC

100 μg APC conjugated

$670
PA1910-PE

100 μg PE conjugated

$670
PA1910-iFluor647

100 μg iFluor647 conjugated

$670
PA1910-carrier-free

Carrier Free

$370

More conjugates/formats

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PA1910
Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00

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