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- Table of Contents
1 Citations
Facts about Netrin receptor DCC.
Its association with UNC5 proteins may trigger signaling for axon repulsion. Additionally, it functions as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
Human | |
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Gene Name: | DCC |
Uniprot: | P43146 |
Entrez: | 1630 |
Belongs to: |
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immunoglobulin superfamily |
Colorectal cancer suppressor; CRC18; CRCR1; DCC; deleted in colorectal cancer protein; deleted in colorectal carcinoma; IGDCC1colorectal tumor suppressor; Immunoglobulin superfamily DCC subclass member 1; immunoglobulin superfamily, DCC subclass, member 1; netrin receptor DCC; Tumor suppressor protein DCC
Mass (kDA):
158.457 kDA
Human | |
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Location: | 18q21.2 |
Sequence: | 18; NC_000018.10 (52340172..53535899) |
Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells.
Membrane; Single-pass type I membrane protein.
PMID: 7926722 by Hedrick L., et al. The DCC gene product in cellular differentiation and colorectal tumorigenesis.
PMID: 2294591 by Fearon E.R., et al. Identification of a chromosome 18q gene that is altered in colorectal cancers.
*More publications can be found for each product on its corresponding product page