Anti-CRSP130 Antibody

Product Name

Anti-CRSP130 Antibody

View all MED23 Antibodies

SKU/Catalog Number

A03859-1

Size

100μl

Form

Liquid

Description

Boster Bio Anti-CRSP130 Antibody catalog # A03859-1. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-CRSP130 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03859-1)

Host

Rabbit

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from the N-terminal region of human CRSP130. at AA rangle: 10-90

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A03859-1 is reactive to MED23 in Human, Mouse, Rat

Applications

A03859-1 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

39 kDa

Calculated molecular weight

156474 MW

Background of MED23

Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier.

Chong J.A.et.al. (1995)Cell 80:949-957
Schoenherr C.J.et.al.(1995)Science 267:1360-1363
Scholl T.et.al.(1996)J. Immunol. 156:1448-1457
Lunyak V.V.et.al. (2002)Science 298:1747-1752

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB, 1:500-1:2000

Validation Images & Assay Conditions

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Western Blot (WB) analysis of specific cells using CRSP130 Polyclonal antibody.

Gene/Protein Information For MED23 (Source: Uniprot.org, NCBI)

Alternative Names

130 kDa transcriptional co-activator; 133 kDa transcriptional co-activator; CRSP130; DRIP130DKFZp434H0117; mediator complex subunit 23CRSP133; Protein sur-2 homolog; subunit 3, 130kDa; Transcriptional coactivator CRSP130; Vitamin D3 receptor-interacting protein complex 130 kDa component MED23 ARC130, CRSP130, CRSP133, CRSP3, DRIP130, MRT18, SUR-2, SUR2 mediator complex subunit 23 mediator of RNA polymerase II transcription subunit 23|130 kDa transcriptional co-activator|133 kDa transcriptional co-activator|activator-recruited cofactor 130 kDa component|cofactor required for Sp1 transcriptional activation subunit 3|mental retardation, non-syndromic, autosomal recessive, 18|vitamin D3 receptor interacting protein

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