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Product Info Summary
| SKU: | A05002 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-CRMP1 Antibody
SKU/Catalog Number
A05002
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-CRMP1 Antibody (Catalog # A05002). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
CRMP1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-CRMP1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A05002)
Host
Rabbit
Contents
CRMP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
CRMP1 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human CRMP1. The immunogen is located within the last 50 amino acids of CRMP1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
SKI2W antibody is human, mouse and rat reactive. At least two isoforms of SKI2W are known to exist; this antibody will detect both isoforms.
Reactive Species
A05002 is reactive to CRMP1 in Human, Mouse, Rat
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
62184 MW
Background of CRMP1
Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain where they play major roles in axonal outgrowth, neurite differentiation, and apoptosis. Their continued expression in areas of high synaptic remodeling such as the cerebellum, hippocampus, and the olfactory system suggests that these proteins may also be involved in adult brain plasticity. CRMP-1 was initially identified as a dihydro-pyrimidinase expressed exclusively in brain; later studies have shown that it is involved with neurotrophin (NT) 3-induced neurite formation and outgrowth. CRMP-1 localization switches from axonal to somatodendritic when neurons reach functional maturity, suggesting that it is involved in early neuronal differentiation as well as in later processes related to the survival or death of the newly generated neurons.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A05002 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
CRMP1 antibody can be used for the detection of CRMP1 by Western blot at 0.5 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2 μg/mL. For immunofluorescence start at 10 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of CRMP1 in human brain tissue lysate with CRMP1 antibody at (A) 1 and (B) 2 μg/mL.
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Immunohistochemistry of CRMP in human brain tissue with CRMP antibody at 2 μg/mL.
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Immunofluorescence of CRMP1 in Human Brain cells with CRMP1 antibody at 10 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For CRMP1 (Source: Uniprot.org, NCBI)
Gene Name
CRMP1
Full Name
Dihydropyrimidinase-related protein 1
Weight
62184 MW
Superfamily
metallo-dependent hydrolases superfamily
Alternative Names
DRP1, DRP-1, CRMP-1, DPYSL1, ULIP-3, ULIP3, Dihydropyrimidinase-related protein 1, Collapsin response mediator protein 1 CRMP1 CRMP-1, DPYSL1, DRP-1, DRP1, ULIP-3 collapsin response mediator protein 1 dihydropyrimidinase-related protein 1|dihydropyrimidinase-like 1|inactive dihydropyrimidinase|unc-33-like phosphoprotein 3
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CRMP1, check out the CRMP1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CRMP1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-CRMP1 Antibody (A05002)
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