Anti-CDK5R1/P35 Antibody

Product Name

Anti-CDK5R1/P35 Antibody

View all CDK5 Activator 1 Antibodies

SKU/Catalog Number

A02595

Size

100 µl

Form

Liquid

Description

Boster Bio Anti-CDK5R1/P35 Antibody (Catalog # A02595). Tested in WB, IF applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-CDK5R1/P35 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02595)

Host

Rabbit

Contents

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Synthesized peptide derived from internal of human CDK5R1.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A02595 is reactive to CDK5R1 in Human, Mouse, Rat

Reconstitution

Calculated molecular weight

34060 MW

Background of CDK5 Activator 1

p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.

Tsai L.-H., Nature 371:419-423(1994).
Patrick G.N., Nature 402:615-622(1999).
Kesavapany S., J. Neurosci. 24:4421-4431(2004).

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A02595 is guaranteed for IF, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blotting: 1:500~1:3000

Immunofluorescence: 1:100~1:500

Validation Images & Assay Conditions

Gene/Protein Information For CDK5R1 (Source: Uniprot.org, NCBI)

Alternative Names

Cyclin-dependent kinase 5 activator 1;CDK5 activator 1;Cyclin-dependent kinase 5 regulatory subunit 1;TPKII regulatory subunit;Cyclin-dependent kinase 5 activator 1, p35;p35;Cyclin-dependent kinase 5 activator 1, p25;p25;Tau protein kinase II 23 kDa subunit;p23;CDK5R1;CDK5R, NCK5A; CDK5R1 CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a cyclin dependent kinase 5 regulatory subunit 1 cyclin-dependent kinase 5 activator 1|CDK5 activator 1|TPKII regulatory subunit|neuronal CDK5 activator|regulatory partner for CDK5 kinase|tau protein kinase II 23kDa subunit

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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