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- Table of Contents
Facts about Cyclin-dependent kinase 5 activator 1.
Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII.
Human | |
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Gene Name: | CDK5R1 |
Uniprot: | Q15078 |
Entrez: | 8851 |
Belongs to: |
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cyclin-dependent kinase 5 activator family |
CDK5 Activator 1; CDK5P35; CDK5R; CDK5R1; cyclin-dependent kinase 5 activator 1; Cyclin-dependent kinase 5 regulatory subunit 1; cyclin-dependent kinase 5, regulatory subunit 1 (p35); MGC33831; NCK5A; Neuronal CDK5 Activator; p23; p25; p35; p35nck5a; regulatory partner for CDK5 kinase; tau protein kinase II 23kDa subunit; TPKII Regulatory Subunit
Mass (kDA):
34.06 kDA
Human | |
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Location: | 17q11.2 |
Sequence: | 17; NC_000017.11 (32485028..32491256) |
Brain and neuron specific.
[Cyclin-dependent kinase 5 activator 1, p35]: Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, neuron projection. In the primary cortical neurons, p35 is present in the peripheries and nerve terminals.; [Cyclin-dependent kinase 5 activator 1, p25]: Nucleus. Cytoplasm, perinuclear region. Perikaryon. The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear regions. In the primary cortical neurons, p25 is primarily concentrated in the cell soma and is largely absent from neurites.
PMID: 8090221 by Tsai L.-H., et al. p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5.
PMID: 10604467 by Patrick G.N., et al. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration.