CDK5R1 Antibodies

Cyclin-dependent kinase 5 activator 1 (CDK5R1)

p35 is a neuron specific activator of CDK5. The intricate p35/CDK5 is required for neurite outgrowth and cortical lamination.

Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII.

Gene Information

Human
Gene Name:	CDK5R1
Uniprot:	Q15078
Entrez:	8851

Family

Belongs to:
cyclin-dependent kinase 5 activator family

Alternative Names

CDK5 Activator 1; CDK5P35; CDK5R; CDK5R1; cyclin-dependent kinase 5 activator 1; Cyclin-dependent kinase 5 regulatory subunit 1; cyclin-dependent kinase 5, regulatory subunit 1 (p35); MGC33831; NCK5A; Neuronal CDK5 Activator; p23; p25; p35; p35nck5a; regulatory partner for CDK5 kinase; tau protein kinase II 23kDa subunit; TPKII Regulatory Subunit

Molecular Weight

Mass (kDA):
34.06 kDA

Genomic Context

Human
Location:	17q11.2
Sequence:	17; NC_000017.11 (32485028..32491256)

Tissue Specificity

Brain and neuron specific.

Subcellular Localizations

[Cyclin-dependent kinase 5 activator 1, p35]: Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, neuron projection. In the primary cortical neurons, p35 is present in the peripheries and nerve terminals.; [Cyclin-dependent kinase 5 activator 1, p25]: Nucleus. Cytoplasm, perinuclear region. Perikaryon. The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear regions. In the primary cortical neurons, p25 is primarily concentrated in the cell soma and is largely absent from neurites.

Diseases

• Malignant Neoplasms
• Neoplasms
• Nervousness
• Alzheimer's Disease
• Neuroblastoma
• Cholangiocarcinoma
• Melanoma
• Neurodegenerative Disorders
• Parkinson Disease
• Cardiovascular Diseases
• Tumor Angiogenesis
• Meningeal Neoplasms

• Neurofibrillary Tangles
• Meningioma
• Cell Invasion
• Nerve Degeneration
• Neurofibromatosis 1
• Cognition Disorders
• Neurotoxicity Syndromes

Interacting Proteins

• CDK5
• MTUS2

Pathways

• Translation
• Cell Cycle
• System Development
• Cell Death
• Nervous System Development
• Central Nervous System Development
• Hyperphosphorylation
• Cell Proliferation
• Cell Migration
• Programmed Cell Death
• Autophagic Cell Death
• Insulin Secretion
• Apoptotic Signaling Pathway

• Mrna Destabilization
• Senescence
• Drug Resistance
• Cell Differentiation
• Cell Growth
• Angiogenesis
• Pathogenesis

PTMs

• Phosphorylation

• Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CDK5R1

Boster Bio - Best Uses Of The CDK5R1 Marker

This review will focus on two products from BosterBio: the anti-CDK5 antibody as well as the cell-based ELISA kits. I'll also discuss the pros and cons of each product. If you are looking to purchase a product, but aren’t sure which one to choose, Boster's anti CDK5 antibody is a good choice.

Boster Bio's anti CDK5 antibody

Many suppliers offer anti CDK5 anti-CDK5 antibodies. This antibody is specific for the CDK5 regulatory subunit 1. This molecule may also be known as CDK5P35, NCK5A, or p23. Some homologs are found in mice, rats, and monkeys. Here's a comparison of these products. Boster Bio has an anti-CDK5 monoclonal immunoglobulin that is specific to human CDK5 and will be useful for your experiments.

CDK5R1 (an essential cellular protein) plays a critical role in neuronal development and cell cycle arrest. This protein is also involved with cell migration and differentiation. It is also involved in the prevention of abortive cell-cycle re-entry. Researchers can identify this protein using an antibody. This helps them understand how cells react to different stimuli.

Boster Bio's cell-based ELISA Kit

Boster Bio's cell based ELIISA kits for the CDK5R1 protein marker measures the presence of both proteins in a microplate. This allows for both total protein and phosphorylation levels to be measured without the need for lysate preparation. This kit is compatible with both non-phosphorylated and phospho-specific targets.

The CDK5R1 Cell Based ELISA kit is easy to use and has a wide range. The cells must first be seeded on a 96 well plate with a clear top. Non-adherent cells may be treated with polyL-lysine. The kit must be stored at 4 degrees Celsius.