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Product Info Summary
| SKU: | A02631-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IF, ICC, WB |
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Product info
Product Name
Anti-Caspase-6 CASP6 Antibody
SKU/Catalog Number
A02631-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Caspase-6 CASP6 Antibody (Catalog # A02631-1). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human.
Storage & Handling
Caspase-6 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Caspase-6 CASP6 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02631-1)
Host
Rabbit
Contents
Caspase-6 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Caspase-6 antibody was raised against a 15 amino acid synthetic peptide from near the center of human Caspase-6. The immunogen is located within amino acids 160 - 210 of Caspase-6.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
Depending on cell lines or tissues used, either full-length or other cleavage products may be observed.
Reactive Species
A02631-1 is reactive to CASP6 in Human
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
33310 MW
Background of Caspase-6
Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-6 is an executioner caspase that was identified based on its homology with human caspases 2 and 3 as well as the C. elegans cell death protein CED-3. It possesses two isoforms, of which only the longer form possesses protease activity. Caspase-6 is highly expressed in adult brain and may play a role in several neuronal pathologies.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A02631-1 is guaranteed for ELISA, IF, ICC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Casp-6 antibody can be used for the detection of Caspase-6 by Western blot at 1 and 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 1 μg/mL. For immunofluorescence start at 10 μg/mL.
Antibody validated: Western Blot in human samples; Immunocytochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Caspase-6 in MCF7 cell lysate with Caspase-6 antibody (IN) at (A) 1 and (B) 2 μg/mL.
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Immunocytochemistry of caspase-6 in MCF7 with caspase-6 antibody at 1 μg/mL.
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Immunofluorescence of Caspase 6 in MCF7 cells with Caspase 6 antibody at 10 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For CASP6 (Source: Uniprot.org, NCBI)
Gene Name
CASP6
Full Name
Caspase-6
Weight
33310 MW
Superfamily
peptidase C14A family
Alternative Names
MCH2, MCH2, Caspase-6, Apoptotic protease Mch-2, CASP-6 CASP6 MCH2 caspase 6 caspase-6|apoptotic protease MCH-2|caspase 6, apoptosis-related cysteine peptidase|caspase 6, apoptosis-related cysteine protease
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CASP6, check out the CASP6 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CASP6: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Caspase-6 CASP6 Antibody (A02631-1)
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