Caspase-6 Antibodies

Caspase-6 (CASP6)

Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, in addition to lamins.

Overexpression promotes programmed cell death. .

Gene Information

Human
Gene Name:	CASP6
Uniprot:	P55212
Entrez:	839

Family

Belongs to:
peptidase C14A family

Alternative Names

Apoptotic protease Mch-2; CASP6; CASP-6; caspase 6, apoptosis-related cysteine peptidase; caspase 6, apoptosis-related cysteine protease; Caspase6; Caspase-6; EC 3.4.22; Mch2; MCH2EC 3.4.22.59

Molecular Weight

Mass (kDA):
33.31 kDA

Genomic Context

Human
Location:	4q25
Sequence:	4; NC_000004.12 (109688628..109703445, complement)

Subcellular Localizations

Cytoplasm.

Diseases

• Neoplasms
• Malignant Neoplasms
• Alzheimer's Disease
• Carcinoma
• Leukemia
• Huntington Disease
• Malignant Neoplasm Of Breast
• Malignant Paraganglionic Neoplasm
• Nerve Degeneration
• Neurodegenerative Disorders
• Mammary Neoplasms
• Tissue Adhesions
• Glioma

• Stomach Neoplasms
• Neoplasm Metastasis
• Neurofibrillary Tangles
• Colonic Neoplasms
• Lung Neoplasms
• Melanoma
• Adenocarcinoma

Interacting Proteins

• CASP3
• SATB1

Pathways

• Cell Death
• Proteolysis
• Pathogenesis
• Localization
• Induction Of Apoptosis
• Programmed Cell Death
• Cell Cycle
• Apoptotic Process
• Cell Proliferation
• Cell Differentiation
• Translation
• Neuroprotection
• Cellular Homeostasis

• Reverse Transcription
• Cell Growth
• Cell Adhesion
• Dna Damage Checkpoint
• Glycosylation
• Dna Repair
• Protein Folding

PTMs

• Cleavage
• Phosphorylation
• Glycosylation
• Deacetylation
• Acetylation

• Methylation
• Dephosphorylation
• Oxidation
• Deglycosylation
• Ubiquitination

Research Areas

• Apoptosis
• Cancer
• Caspases

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CASP6

Best Uses Of The CASP6 Marker

Although you may have heard of the CASP6 marker before, perhaps you weren't aware of the educational resources it offers. Boster Bio provides educational resources in PDF format that you can distribute to your students. Make sure you properly refer to the resources and link to the site. It is always recommended to link back to the original source, to allow your students to get more information about the CASP6 Marker.

Information

Researchers have found that some human CASP6 SNPs encode missense variants and others are associated with a lower risk of developing Alzheimer's disease (AD). The gene could be a therapeutic target for Alzheimer's disease, since the activity of the active form of the enzyme is linked to cognitive impairment and progress of the disease. The SNPs in CASP6 are associated with a lower likelihood of developing the disease and a variety of rare human CASP6 SNPs are associated with a decreased chance of age-related casp6-mediated neurodegeneration.

The CASP6 gene is part of the peptidase C14A famiy , and is involved in apoptosis as well as programmed cell death. When expressed excessively it triggers the death of cells in a programmed manner and contributes to a variety of diseases that include thoracic cancer as well as myocardial infarction. It also plays a part in the superpathway closely linked to survival FAS signaling.

Recent research has revealed that CASP6 markedly decreased the hyperalgesia and allodynia induced by CFA in WT mice, when compared to Casp6/ mice. Researchers believe this marker may be involved in the control and maintenance of inflammatory and mechanical pain. But further studies are needed to determine how CASP6 affects health and disease. If you're a doctor ensure that you check your CASP6 level to ensure it is accurate and completeness.

Rare human CASP6 variants identified by multiple sequence alignments and the NCBI SNP database are highlighted in bold. These human caspases may also be represented using Pymol structures that are derived from 2WDP chains A28 and. The apo form of their genes is shown orange, while the AcVEID-CHO bound version of their genes are shown in blue. There are rare variations in the expression of the CASP6 gene among humans.

Resources

The Caspase 6 marker is part of the peptidase C14A peptidase family. The enzyme causes anapoptosis (a programmed death of cells) in cells. Overexpression of Caspase 6 promotes programmed cell death. Caspase 6 is associated with thoracic cancer, myocardial injury, and other diseases. Caspase 6 is involved in several superpathways, such as DR3 signaling and the survival FAS signaling cascade.

PDFs

The CASP6 marker is an effective instrument for detecting enzyme activity in cells. It can detect the activities of proteases, caspases and luciferase activity in addition to its luciferase activity. Bosterbio offers many enzyme activity assay kits in different capacities. Each kit includes 1000 tests and comes in 96 well plates.

The Boster Bio Anti-Bax Antibody Picoband detects the levels of the biomarker in cells, tissues and cells of all types. The antibody is able to detect CASP6 expression levels in tissues, cells organs, as well as other body organs. It reacts with Human, Mouse, and Rat proteins. It is also able to detect the presence of specific kinds of bacteria. For more information, visit bosterbio.com/casp6-marker and browse our catalog.

FAQs

The CASP6 marker is an innovative, high-sensitivity antibody that measures the apoptosis process in its final stages. It measures the activity of caspase-3 which is a key stage in cell death. It is sensitive and specific enough to determine levels in various samples, such as blood as well as plasma, tissue and. The CASP6 antibody is particularly useful in predicting the state of apoptosis of COVID-19.