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Product Info Summary
| SKU: | A04906 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IHC-P |
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Product info
Product Name
Anti-CARMA2 CARD14 Antibody
SKU/Catalog Number
A04906
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-CARMA2 CARD14 Antibody (Catalog # A04906). Tested in ELISA, IHC-P applications. This antibody reacts with Human.
Storage & Handling
CARMA2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-CARMA2 CARD14 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A04906)
Host
Rabbit
Contents
CARMA2 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
CARMA2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human CARMA2. The immunogen is located within the last 50 amino acids of CARMA2.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
CARMA2 antibody is human specific. At least three isoforms of CARMA2 are known to exist; this antibody will only detect isoform 1. CARMA2 antibody is predicted not to cross-react with other CARMA proteins.
Reactive Species
A04906 is reactive to CARD14 in Human
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
113270 MW
Background of CARD14
CARMA proteins belong to the membrane-associated guan-ylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA2 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-κB activation. When expressed in cells, this protein activated NF-κB and induced the phosphorylation of BCL10 Alternative splicing of CARMA2 results in isoforms that possess differential effects on NF-κB activation and endoplasmic reticulum stress-induced cell death.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A04906 is guaranteed for ELISA, IHC-P Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
CARMA2 antibody can be used for detection of CARMA2 by immunohistochemistry at 5 μg/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Immunohistochemistry of CARMA2 in human placenta tissue with CARMA2 antibody at 5 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For CARD14 (Source: Uniprot.org, NCBI)
Gene Name
CARD14
Full Name
Caspase recruitment domain-containing protein 14
Weight
113270 MW
Alternative Names
PRP, PSS1, BIMP2, CARMA2, PSORS2, Caspase recruitment domain-containing protein 14, CARD-containing MAGUK protein 2, Carma 2 CARD14 BIMP2, CARMA2, PRP, PSORS2, PSS1 caspase recruitment domain family member 14 caspase recruitment domain-containing protein 14|CARD-containing MAGUK protein 2|bcl10-interacting maguk protein 2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on CARD14, check out the CARD14 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for CARD14: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-CARMA2 CARD14 Antibody (A04906)
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