Anti-BRUCE BIRC6 Antibody

Product Name

Anti-BRUCE BIRC6 Antibody

View all Birc6 Antibodies

SKU/Catalog Number

A01773

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-BRUCE BIRC6 Antibody (Catalog # A01773). Tested in ELISA, IHC-P applications. This antibody reacts with Human.

Storage & Handling

BRUCE antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-BRUCE BIRC6 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A01773)

Host

Rabbit

Contents

BRUCE Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

BRUCE antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human BRUCE. The immunogen is located within amino acids 4760 - 4810 of BRUCE.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

BRUCE antibody is human specific. Multiple isoforms of BRUCE are known to exist.

Reactive Species

A01773 is reactive to BIRC6 in Human

Reconstitution

Observed Molecular Weight

68 kDa

Calculated molecular weight

530255 MW

Background of Birc6

Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. BRUCE, also known as BIRC6, is an IAP family member protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. BRUCE regulates p53 and the mitochondrial pathway of apoptosis by facilitating the degradation of apoptotic proteins such as Caspase-9 and SMAC by ubiquitination.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A01773 is guaranteed for ELISA, IHC-P Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

BRUCE antibody can be used for detection of BRUCE by immunohistochemistry at 5 μg/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

Gene/Protein Information For BIRC6 (Source: Uniprot.org, NCBI)

Alternative Names

BRUCE, APOLLON, KIAA1289, Baculoviral IAP repeat-containing protein 6, BIR repeat-containing ubiquitin-conjugating enzyme, BRUCE Birc6|A430032G04Rik, A430040A19Rik, AA501170, Bruc, Bruce, D630005A10Rik, mKIAA1289|baculoviral IAP repeat-containing 6|baculoviral IAP repeat-containing protein 6|BIR repeat-containing ubiquitin-conjugating enzyme|RING-type E3 ubiquitin transferase BIRC6|apollon|baculovirus inhibitor of apoptosis repeat containing ubiquitin-conjugating enzyme|baculovirus inhibitor of apoptosis repeat containing ubiquitin-conjugating enzyme; accccbaculoviral IAP repeat-containing 6|ubiquitin-conjugating BIR domain enzyme apollon

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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