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Product Info Summary
| SKU: | A03107 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human |
| Host: | Rabbit |
| Application: | ELISA, IF, IHC-P, WB |
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Product info
Product Name
Anti-Bnip3L Antibody
SKU/Catalog Number
A03107
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Bnip3L Antibody (Catalog # A03107). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human.
Storage & Handling
Bnip3L antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Bnip3L Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A03107)
Host
Rabbit
Contents
Bnip3L Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Bnip3L antibody was raised against a 16 amino acid peptide near the center of human Bnip3L. The immunogen is located within amino acids 60 - 110 of Bnip3L.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least two isoforms of Bnip3L are known to exist.
Reactive Species
A03107 is reactive to BNIP3L in Human
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
23930 MW
Background of BNIP3L
Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, Hrk, Nip3, and Bim, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bnip3L, Bnip3alpha, and Nix (for Nip3-like protein X). Bnip3L/Bnip3alpha/Nix is a homolog of the E1B 19K/Bcl-2 binding and pro-apoptotic protein Bnip3. Overexpression of Bnip3L induces apoptosis. Bnip3L interacts with and overcomes suppresses by Bcl-2 and Bcl-xL. Bnip3L is localized in mitochondria. The messenger RNA of Bnip3L is ubiquitously expressed in human tissues. Bnip3L and Bnip3 form a new subfamily of the pro-apoptotic mitochondrial proteins.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A03107 is guaranteed for ELISA, IF, IHC-P, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Bnip3L antibody can be used for detection of Bnip3L by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2 μg/mL. For immunofluorescence start at 10 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of Bnip3L in K562 whole cell lysate in (A) the absence
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Immunohistochemical staining of human kidney tissue using Bnip3L antibody at 2 μg/mL.
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Immunofluorescence of Bnip3L in Human Kidney tissue with Bnip3L antibody at 10 μg/mL.
Protein Target Info & Infographic
Gene/Protein Information For BNIP3L (Source: Uniprot.org, NCBI)
Gene Name
BNIP3L
Full Name
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
Weight
23930 MW
Superfamily
NIP3 family
Alternative Names
NIX, BNIP3a, BNIP3A, BNIP3H, NIX, Adenovirus E1B19K-binding protein B5, NIP3L BNIP3L BNIP3a, NIX BCL2 interacting protein 3 like BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like|BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A|BCL2/adenovirus E1B 19-kd protein-interacting protein 3a|BCL2/adenovirus E1B 19kDa interacting protein 3 like|NIP-3-like protein X|NIP3-like protein X|NIP3L|adenovirus E1B19k-binding protein B5
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on BNIP3L, check out the BNIP3L Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for BNIP3L: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Bnip3L Antibody (A03107)
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