Anti-BACE BACE1 Antibody

BACE-1 antibody

Boster Bio Anti-BACE BACE1 Antibody (Catalog # A00322). Tested in ELISA, WB, ICC, IHC-P, IF applications. This antibody reacts with Human, Mouse. Cited in 3 publication(s).

Product Info Summary

SKU: A00322
Size: 0.1 mg
Reactive Species: Human, Mouse
Host: Rabbit
Application: ELISA, IF, IHC-P, ICC, WB

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Product Name

Anti-BACE BACE1 Antibody

View all BACE-1 Antibodies

SKU/Catalog Number

A00322

Size

0.1 mg

Form

Liquid

Description

Boster Bio Anti-BACE BACE1 Antibody (Catalog # A00322). Tested in ELISA, WB, ICC, IHC-P, IF applications. This antibody reacts with Human, Mouse.

Storage & Handling

BACE antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Cite This Product

Anti-BACE BACE1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A00322)

Host

Rabbit

Contents

BACE Antibody is supplied in PBS containing 0.02% sodium azide.

Clonality

Polyclonal

Isotype

IgG

Immunogen

Anti-BACE antibody was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of human BACE. The immunogen is located within the last 50 amino acids of BACE.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

CXCR3 antibody is human, mouse and rat reactive. At least two isoforms of CXCR3 are known to exist; this antibody will detect both isoforms.

Reactive Species

A00322 is reactive to BACE1 in Human, Mouse

Reconstitution

Observed Molecular Weight

68 kDa

Calculated molecular weight

55764 MW

Background of BACE-1

Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by two proteases. APP is first cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide, which is deposited in the brains of all suffers of Alzheimer's disease. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Applications

A00322 is guaranteed for ELISA, IF, IHC-P, ICC, WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB: 1 μg/mL; IHC-P: 2.5 μg/mL; ICC: 10 μg/mL; IF: 20 μg/mL.
Antibody validated: Western Blot in human and mouse samples; Immunohistochemistry, Immunocytochemistry and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Validation Images & Assay Conditions

Gene/Protein Information For BACE1 (Source: Uniprot.org, NCBI)

Gene Name

BACE1

Full Name

Beta-secretase 1

Weight

55764 MW

Superfamily

peptidase A1 family

Alternative Names

ASP2, BACE, HSPC104, KIAA1149, Beta-secretase 1, Aspartyl protease 2, ASP2 BACE1 ASP2, BACE, HSPC104 beta-secretase 1 beta-secretase 1|APP beta-secretase|asp 2|aspartyl protease 2|beta-secretase 1 precursor variant 1|beta-site APP cleaving enzyme 1|beta-site APP-cleaving enzyme|beta-site amyloid beta A4 precursor protein-cleaving enzyme|memapsin-2|membrane-associated aspartic protease 2|transmembrane aspartic proteinase Asp2

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on BACE1, check out the BACE1 Infographic

BACE1 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for BACE1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

Hello CJ!

A00322 has been cited in 3 publications:

*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.

Ou Qiao,Xinyu Zhang,Yi Zhang et al.Cerebralcare Granule® enhances memantine hydrochloride efficacy in APP/PS1 mice by ameliorating amyloid pathology and cognitive functions,08 April 2021,PREPRINT (Version 1) available at Research Square [https://doi.org/10.21203/rs.3.rs-366097/v1]
Species: Mouse
A00322 usage in article: APP:WB, SAMPLE:BRAIN TISSUE, DILUTION:NA

Wu J,Qu JQ,Zhou YJ,Zhou YJ,Li YY,Huang NQ,Deng CM,Luo Y.Icariin improves cognitive deficits by reducing the deposition of β-amyloid peptide and inhibition of neurons apoptosis in SAMP8 mice.Neuroreport.2020 Jun 7;31(9):663-671.doi:10.1097/WNR.000000000000
Species: Mouse
A00322 usage in article: APP:WB, SAMPLE:HIPPOCAMPUS TISSUE, DILUTION:NA

Expression of ?-site APP-cleaving enzyme 1 in the hippocampal tissue of an insulin-resistant rat model of Alzheimer's disease

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Order DetailsPrice
A00322-0.1 mg

0.1 mg

$449

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*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$449.00

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