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Beta-secretase 1 Antibodies
AND BACE1 ELISA kits, Beta-secretase 1 Proteins
Many biological assays use antibodies to detect Beta-secretase 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Beta-secretase 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Beta-secretase 1 antibodies...
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BACE1 Infographic by Boster Bio
All BACE1 Products
Product
Figures
Specificity
Applications
Price
Anti-BACE1/Bace Rabbit Monoclonal Antibody
2 Citations 1 Q&As
Human, Mouse, Rat
IP, WB
$370
Cat # M00322
100 μl
Cat # M00322
100 μl
Anti-Beta-secretase 1 BACE1 Antibody
1 Citations
Human, Mouse, Rat
IF, IHC, ICC, WB
$405
Cat # A00322-2
100ul
Cat # A00322-2
100ul
BACE1 Overview
Facts about Beta-secretase 1.
Beta-secretase 1 (BACE1)
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of this A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, along with a corresponding cell-associated C-terminal fragment that's later released by gamma-secretase.
Cleaves APP with much more catalytic efficiency than for the wild-type. .
Gene Information
| Human | |
|---|---|
| Gene Name: | BACE1 |
| Uniprot: | P56817 |
| Entrez: | 23621 |
Family
| Belongs to: |
|---|
| peptidase A1 family |
Alternative Names
APP beta-secretase; ASP2; Aspartyl protease 2; BACE1; BACE-1; BACEAsp 2; beta-secretase 1 precursor variant 1; beta-secretase 1; beta-site amyloid beta A4 precursor protein-cleaving enzyme; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; beta-site APP-cleaving enzyme 1; beta-site APP-cleaving enzyme; EC 3.4.23; EC 3.4.23.46; FLJ90568; HSPC104; KIAA1149; memapsin-2; Membrane-associated aspartic protease 2; transmembrane aspartic proteinase Asp2
Molecular Weight
Mass (kDA):
55.764 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q23.3 |
| Sequence: | 11; NC_000011.10 (117285207..117316256, complement) |
Tissue Specificity
Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum. Endosome. Cell surface. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane raft. Lysosome. Late endosome. Early endosome. Recycling endosome. Cell projection, axon. Cell projection, dendrite. Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface (PubMed:17425515, PubMed:11466313). Colocalizatio
Diseases
- Alzheimer's Disease
- Plaque, Amyloid
- Senile Plaques
- Neuroblastoma
- Dental Plaque
- Neurodegenerative Disorders
- Nerve Degeneration
- Dementia
- Alzheimer Disease, Familial
- Neurofibrillary Tangles
- Nervousness
- Impaired Cognition
Interacting Proteins
- ADAM10
- APP
- Clec4g
- FLOT2
- GGA1
- GGA2
- GGA3
- IAPP
- ITM2B
- KCNC4
Pathways
- Pathogenesis
- Secretion
- Proteolysis
- Localization
- Transport
- Protein Processing
- Aging
- Cell Death
- Secretory Pathway
- Translation
- Endocytosis
- Glycosylation
- Rna Interference
PTMs
- Cleavage
- Phosphorylation
- Glycosylation
- Gamma-cleavage
- Biotinylation
- Ubiquitination
- Methylation
- Ribosylation
- Reduction
- Oxidation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BACE1
bosterbio.com/bosterbio-gene-info-cards/BACE1
References
PMID: 10531052 by Vassar R., et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
PMID: 10591214 by Sinha S., et al. Purification and cloning of amyloid precursor protein beta-secretase from human brain.
4 Publications of Boster Beta-secretase 1 Antibodies & ELISA Kits
- PubMed ID: 10.3892/etm.2015.2391, Expression of β-site APP-cleaving enzyme 1 in the hippocampal tissue of an insu...
- PubMed ID: -, Ou Qiao,Xinyu Zhang,Yi Zhang et al.Cerebralcare Granule® enhances memantine hyd...
- PubMed ID: 32427716, Wu J,Qu JQ,Zhou YJ,Zhou YJ,Li YY,Huang NQ,Deng CM,Luo Y.Icariin improves cogniti...
- PubMed ID: 26136993, Expression of ?-site APP-cleaving enzyme 1 in the hippocampal tissue of an insul...
*More publications can be found for each product on its corresponding product page