Product Info Summary
SKU: | A02144 |
---|---|
Size: | 100 µl |
Reactive Species: | Human |
Host: | Rabbit |
Application: | IHC, WB |
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Product info
Product Name
Anti-AOX1/Aldehyde Oxidase Antibody
View all Aldehyde Oxidase 1/AOX1 Antibodies
SKU/Catalog Number
A02144
Size
100 µl
Form
Liquid
Description
Boster Bio Anti-AOX1/Aldehyde Oxidase Antibody (Catalog # A02144). Tested in WB, IHC applications. This antibody reacts with Human.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-AOX1/Aldehyde Oxidase Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02144)
Host
Rabbit
Contents
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from internal of human AOX1.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A02144 is reactive to AOX1 in Human
Reconstitution
Calculated molecular weight
147918 MW
Background of Aldehyde Oxidase 1/AOX1
Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and N-methylphthalazinium, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis.
Wright R.M., Proc. Natl. Acad. Sci. U.S.A. 90:10690-10694(1993).
Wright R.M., Redox Rep. 3:135-144(1997).
Hillier L.W., Nature 434:724-731(2005).
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A02144 is guaranteed for IHC, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Validation Images & Assay Conditions
Click image to see more details
Western blot analysis of extracts from HeLa cells, using AOX1 antibody A02144.
Click image to see more details
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using AOX1 antibody A02144.
Protein Target Info & Infographic
Gene/Protein Information For AOX1 (Source: Uniprot.org, NCBI)
Gene Name
AOX1
Full Name
Aldehyde oxidase
Weight
147918 MW
Superfamily
xanthine dehydrogenase family
Alternative Names
Aldehyde oxidase;1.2.3.1 ;Aldehyde oxidase 1;Azaheterocycle hydroxylase;1.17.3.-;AOX1;AO; AOX1 AO, AOH1 aldehyde oxidase 1 aldehyde oxidase|azaheterocycle hydroxylase
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on AOX1, check out the AOX1 Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for AOX1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-AOX1/Aldehyde Oxidase Antibody (A02144)
Hello CJ!
A02144 has been cited in 2 publications:
*The publications in this section are manually curated by our staff scientists. They may differ from Bioz's machine gathered results. Both are accurate. If you find a publication citing this product but is missing from this list, please let us know we will issue you a thank-you coupon.
Aldehyde oxidase 1 promoted the occurrence and development of colorectal cancer by up-regulation of expression of CD133
Zhang W,Chai W,Zhu Z,Li X.Aldehyde oxidase 1 promoted the occurrence and development of colorectal cancer by up-regulation of expression of CD133. Int Immunopharmacol.2020 Aug;85:106618.doi:10.1016/j. intimp.2020.106618.Epub 2020 May 26.PMID:32470878.
Species: Human
A02144 usage in article: APP:IF, SAMPLE:LOVO CELLS, DILUTION:1:400
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