Anti-Antithrombin III/SERPINC1 Antibody Picoband®

Product Name

Anti-Antithrombin III/SERPINC1 Antibody Picoband®

View all Serpin C1/Antithrombin-III Antibodies

SKU/Catalog Number

PA2218

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-Antithrombin III/SERPINC1 Antibody catalog # PA2218. Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Antithrombin III/SERPINC1 Antibody Picoband® (Boster Biological Technology, Pleasanton CA, USA, Catalog # PA2218)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the N-terminus of human Antithrombin III, different from the related mouse and rat sequences by one amino acid.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins

Reactive Species

PA2218 is reactive to SERPINC1 in Human, Mouse, Rat

Reconstitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Observed Molecular Weight

57 kDa

Calculated molecular weight

52602 MW

Background of Serpin C1/Antithrombin-III

Serpin peptidase inhibitor, clade C (antithrombin), member 1, also known as Antithrombin III (AT3) is the most important inhibitor of thrombin OMBIN III and other coagulation proteinases. This gene is mapped to 1q25.1. The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

View more details

Applications

PA2218 is guaranteed for WB Boster Guarantee

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Western blot, 0.1-0.5μg/ml, Human, Rat, Mouse

Positive Control

WB: Rat Testis Tissue, SMMC Cell, JURKAT Cell, RAJI Cell

Validation Images & Assay Conditions

Gene/Protein Information For SERPINC1 (Source: Uniprot.org, NCBI)

Alternative Names

Antithrombin-III;ATIII;Serpin C1;SERPINC1;AT3;PRO0309; SERPINC1 AT3, AT3D, ATIII, ATIII-R2, ATIII-T1, ATIII-T2, THPH7 serpin family C member 1 antithrombin-III|serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1|serpin peptidase inhibitor clade C member 1|serpin peptidase inhibitor, clade C (antithrombin), member 1

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

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