Product Info Summary
SKU: | A09184 |
---|---|
Size: | 100ul |
Reactive Species: | Human, Mouse, Rat |
Host: | Rabbit |
Application: | WB |
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Product info
Product Name
Anti-Alpha-mannosidase 2 MAN2A1 Antibody
View all Alpha-mannosidase II Antibodies
SKU/Catalog Number
A09184
Size
100ul
Form
Liquid
Description
Boster Bio Anti-Alpha-mannosidase 2 MAN2A1 Antibody catalog # A09184. Tested in WB applications. This antibody reacts with Human,Mouse,Rat.
Storage & Handling
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Cite This Product
Anti-Alpha-mannosidase 2 MAN2A1 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A09184)
Host
Rabbit
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Clonality
Polyclonal
Isotype
IgG
Immunogen
Synthesized peptide derived from human CDK5 Activator-binding C42
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Reactive Species
A09184 is reactive to MAN2A1 in Human, Mouse, Rat
Applications
A09184 is guaranteed for WB Boster Guarantee
Observed Molecular Weight
Calculated molecular weight
131141 MW
Background of Alpha-mannosidase II
Required for synapse integrity and synaptic plasticity. During cerebellar synapse formation, essential for the formation and maintenance of parallel fiber and Purkinje cell synapses. When parallel fibers make contact with Purkinje spines, CBLN1 interaction with GRID2 triggers the recruitment of NRXN1 and secretory vesicles to the sites of contact. NRXN1-CBLN1-GRID2 signaling induces presynaptic morphological changes, which may further accumulate pre- and postsynaptic components to promote bidirectional maturation of parallel fiber - Purkinje cell functionnally active synapses by a positive feedback mechanism. Required for CBLN3 export from the endoplasmic reticulum and secretion By similarity.The cerebellin peptide exerts neuromodulatory functions. Directly stimulates norepinephrine release via the adenylate cyclase/PKA-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release By similarity.
Urade Y., Proc. Natl. Acad. Sci. U.S.A. 88:1069-1073(1991).
Ota T., Nat. Genet. 36:40-45(2004).
Mural R.J., Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Assay dilution & Images
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
WB: 1:1000-1:2000
Validation Images & Assay Conditions
![a09184 anti alpha mannosidase 2 man2a1 antibody wb testing 1 a09184 anti alpha mannosidase 2 man2a1 antibody wb testing 1](https://www.bosterbio.com/media/catalog/product/a/0/a09184-anti-alpha-mannosidase-2-man2a1-antibody-wb-testing-1.jpg)
Click image to see more details
Figure 1. Western blotting validation for Anti-Alpha-mannosidase 2 MAN2A1 Antibody A09184
Western blot analysis of extract of various cellsProtein Target Info & Infographic
Gene/Protein Information For MAN2A1 (Source: Uniprot.org, NCBI)
Gene Name
MAN2A1
Full Name
Alpha-mannosidase 2
Weight
131141 MW
Superfamily
glycosyl hydrolase 38 family
Alternative Names
alpha-mannosidase 2; AMan II; EC 3.2.1; EC 3.2.1.114; Golgi alpha-mannosidase II; golgi integral membrane protein 7; GOLIM7; Man II; MANA2MANII; Mannosidase alpha class 2A member 1; mannosidase, alpha type II; mannosidase, alpha, class 2A, member 1; Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase MAN2A1 AMan II, GOLIM7, MANA2, MANII mannosidase alpha class 2A member 1 alpha-mannosidase 2|Golgi alpha-mannosidase II|golgi integral membrane protein 7|mannosidase, alpha type II|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on MAN2A1, check out the MAN2A1 Infographic
![MAN2A1 infographic](/media/images/gene-infographic-example.jpg)
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for MAN2A1: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Alpha-mannosidase 2 MAN2A1 Antibody (A09184)
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