Alpha-mannosidase 2 Antibodies

AND MAN2A1 ELISA kits, Alpha-mannosidase 2 Proteins

Many biological assays use antibodies to detect Alpha-mannosidase 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Alpha-mannosidase 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Alpha-mannosidase 2 antibodies...

We validate the specificity of these antibodies to Alpha-mannosidase 2 by testing them on tissues known to express MAN2A1 positively and negatively. Browse below to find the MAN2A1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MAN2A1 Infographic by Boster Bio

All MAN2A1 Products

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Specificity

Applications

Price

Anti-Alpha-mannosidase 2 MAN2A1 Antibody

Human, Mouse, Rat

$405
Cat # A09184
100ul

Mannosidase II (MAN2A1) (NM_002372) Human Over-expression Lysate

Human

$960
Cat # LS004124
100 µg

MAN2A1 Overview

Facts about Alpha-mannosidase 2.

MAN2A1 3D structure. Source: alphafold

Alpha-mannosidase 2 (MAN2A1)

Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway.

Gene Information

Human
Gene Name:	MAN2A1
Uniprot:	Q16706
Entrez:	4124

Family

Belongs to:

glycosyl hydrolase 38 family

Alternative Names

alpha-mannosidase 2; AMan II; EC 3.2.1; EC 3.2.1.114; Golgi alpha-mannosidase II; golgi integral membrane protein 7; GOLIM7; Man II; MANA2MANII; Mannosidase alpha class 2A member 1; mannosidase, alpha type II; mannosidase, alpha, class 2A, member 1; Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase

Molecular Weight

Mass (kDA):
131.141 kDA

Genomic Context


Human

Location:	5q21.3
Sequence:	5; NC_000005.10 (109689366..109869625)

Subcellular Localizations

Golgi apparatus membrane; Single-pass type II membrane protein.

Diseases

Cholangiocarcinoma
Autoimmunity
Anemia
Nerve Degeneration
Congenital Dyserythropoietic Anemia
Acute Lymphocytic Leukemia
Diabetes Mellitus
Diabetes Mellitus, Non-insulin-dependent
Leukemia

Lupus Erythematosus, Systemic
Inflammation
L1 Acute Lymphoblastic Leukemia
Alzheimer's Disease

Pathways

Glycosylation
Localization
Flight

PTMs

Glycosylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAN2A1

References

PMID: 8524845 by Misago M., et al. Molecular cloning and expression of cDNAs encoding human alpha- mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme.

PMID: 25787250 by Cromer M.K., et al. Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas.