Product Info Summary
SKU: | A02882 |
---|---|
Size: | 0.1 mg |
Reactive Species: | Human, Mouse |
Host: | Rabbit |
Application: | ELISA, WB |
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Product info
Product Name
Anti-Activin receptor type-1B ACVR1B Antibody
View all Activin RIB/ALK-4 Antibodies
SKU/Catalog Number
A02882
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-Activin receptor type-1B ACVR1B Antibody (Catalog # A02882). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.
Storage & Handling
ACVR1B antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-Activin receptor type-1B ACVR1B Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A02882)
Host
Rabbit
Contents
ACVR1B Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
ACVR1B antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of the human ACVR1B. The immunogen is located within amino acids 140 - 190 of ACVR1B.
*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.
Cross-reactivity
At least three isoforms of ACVR1B are known to exist. This antibody is predicted to have no cross-reactivity to ACVR1 or ACVR1C.
Reactive Species
A02882 is reactive to ACVR1B in Human, Mouse
Reconstitution
Observed Molecular Weight
68 kDa
Calculated molecular weight
56807 MW
Background of Activin RIB/ALK-4
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. ACVR1B, also known as activin receptor-like kinase 4 (ALK4), is a type I receptor for activin and plays major roles in cell differentiation, growth arrest and apoptosis. Like another type I activin receptor ACVR1C, ACVR1B can mediate signaling by ligands such as Nodal, Xnr1, GDF-1/3, activin B and activin AB. In Xenopus embryos, expression of a dominant-negative form of ACVR1B blocked all mesoderm-inducing ligands, while expression of a dominant negative ACVR1C only blocked Nodal and Xnr1 signaling, suggesting that the ACVR1B and ACVR1C possess distinct functions.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A02882 is guaranteed for ELISA, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
ACVR1B antibody can be used for detection of ACVR1B by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
Click image to see more details
Western blot analysis of ACVR1B in human kidney tissue lysate with ACVR1B antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Protein Target Info & Infographic
Gene/Protein Information For ACVR1B (Source: Uniprot.org, NCBI)
Gene Name
ACVR1B
Full Name
Activin receptor type-1B
Weight
56807 MW
Superfamily
protein kinase superfamily
Alternative Names
FOP, ALK2, SKR1, TSRI, ACTRI, ACVR1A, ACVRLK2, Activin receptor type-1, Activin receptor type I, ACTR-I ACVR1B ACTRIB, ACVRLK4, ALK4, SKR2 activin A receptor type 1B activin receptor type-1B|activin A receptor, type IB|activin A receptor, type II-like kinase 4|activin receptor-like kinase 4|serine/threonine-protein kinase receptor R2
*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".For more info on ACVR1B, check out the ACVR1B Infographic
We have 30,000+ of these available, one for each gene! Check them out.
In this infographic, you will see the following information for ACVR1B: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].
Specific Publications For Anti-Activin receptor type-1B ACVR1B Antibody (A02882)
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