This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
179 Citations 20 Q&As
96 Citations 18 Q&As
82 Citations 4 Q&As
108 Citations 18 Q&As
118 Citations 5 Q&As
44 Citations 4 Q&As
31 Citations 17 Q&As
50 Citations 16 Q&As
2 Citations
5 Citations
Facts about Vascular endothelial growth factor A.
Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145.
Human | |
---|---|
Gene Name: | VEGFA |
Uniprot: | P15692 |
Entrez: | 7422 |
Belongs to: |
---|
PDGF/VEGF growth factor family |
MVCD1; VAS; vascular endothelial growth factor A; Vascular permeability factor; Vasculotropin; VEGF; VEGFA; VEGF-A; VEGFMGC70609; VPF; VPFvascular endothelial growth factor
Mass (kDA):
27.042 kDA
Human | |
---|---|
Location: | 6p21.1 |
Sequence: | 6; NC_000006.12 (43770209..43786487) |
Isoform VEGF189, isoform VEGF165 and isoform VEGF121 are widely expressed. Isoform VEGF206 and isoform VEGF145 are not widely expressed. A higher level expression seen in pituitary tumors as compared to the pituitary gland.
Secreted. VEGF121 is acidic and freely secreted. VEGF165 is more basic, has heparin-binding properties and, although a significant proportion remains cell-associated, most is freely secreted. VEGF189 is very basic, it is cell-associated after secretion and is bound avidly by heparin and the extracellular matrix, although it may be released as a soluble form by heparin, heparinase or plasmin.
PMID: 2479986 by Leung D.W., et al. Vascular endothelial growth factor is a secreted angiogenic mitogen.
PMID: 2479987 by Keck P.J., et al. Vascular permeability factor, an endothelial cell mitogen related to PDGF.
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page