Key=store_id Key=entity_id, value=54441 Key=attribute_set_id, value=4 Key=type_id, value=simple Key=sku, value=EKC2005 Key=has_options, value=0 Key=required_options, value=0 Key=created_at, value=2019-02-12 00:21:00 Key=updated_at, value=2024-09-26 01:01:46 Key=mst_search_weight, value=0 Key=status, value=Enabled Key=name, value=SYK (Phospho-Tyr348) Colorimetric Cell-Based ELISA Kit Key=cj_search_index Key=publication_count, value=3 Key=qty_in_warehouses Key=is_recurring, value=No Key=visibility, value=Catalog, Search Key=tax_class_id, value=Taxable Goods Key=featured_image, value=Yes Key=fb_product, value= Key=custom_product_page, value=No Key=free_shipping, value=No Key=template, value=cell-based-phospho-elisa-kits Key=price, value=540.0000 Key=weight, value=1.0000 Key=meta_title, value=SYK (Phospho-Tyr348) Colorimetric Cell-Based ELISA Kit Price Key=meta_description, value=SYK (Phospho-Tyr348) Colorimetric Cell-Based ELISA Kit EKC2005 Key=image, value=/b/o/boster-box.png Key=small_image, value=/b/o/boster-box.png Key=thumbnail, value=/b/o/boster-box.png Key=url_key, value=syk-phospho-tyr348-colorimetric-cell-based-elisa-kit-ekc2005-boster Key=url_path, value=syk-phospho-tyr348-colorimetric-cell-based-elisa-kit-ekc2005-boster Key=options_container, value=Product Info Column Key=image_label, value=Boster Kit Box Key=small_image_label, value=Boster Kit Box Key=thumbnail_label, value=Boster Kit Box Key=msrp_display_actual_price_type, value= Key=size, value=1 kit, containing two 96-well plates and all necessary reagents Key=gene_full_name, value=Tyrosine-protein kinase SYK Key=uniprot_id, value=P43405 Key=assay_range, value=> 5000 cells/well Key=sensitivity Key=applications, value=ELISA Key=reactivity, value=Human, Mouse, Rat Key=source_company, value=AssayBiotech CBP1084; Cost: 300 Key=molecular_weight, value=72066 MW Key=product_category, value=Cell-Based ELISA Kits Key=rating_value, value=100 Key=review_count, value=19 Key=cj_related_products, value=Anaphylaxis:PB9902^Basophilic Leukemia:A06564|A00801|M07600^Mast Cell Degranulation:EK0993|EKC2614 Key=special_from_date Key=description, value=The SYK (Phospho-Tyr348) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor SYK (Phospho-Tyr348) protein expression profile in cells. The kit can be used for measuring the relative amounts of SYK (Phospho-Tyr348) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on SYK (Phospho-Tyr348). Key=short_description, value=The SYK (Phospho-Tyr348) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor SYK (Phospho-Tyr348) protein expression profile in cells. The kit can be used for measuring the relative amounts of SYK (Phospho-Tyr348) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on SYK (Phospho-Tyr348). Key=gene_name, value=SYK Key=synonyms, value=Spleen tyrosine kinase;PROTEIN-TYROSINE KINASE SYK Key=sample_type, value=Cell lines Key=kit_components, value=SYK (Phospho-Tyr348) Key=subcellular_localization, value=Cell membrane. Cytoplasm, cytosol. Key=tissue_specificity, value=Widely expressed in hematopoietic cells (at protein level). Within the B-cells compartment it is for instance expressed for pro-B-cells to plasma cells. Key=protein_function, value= Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine- phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR plays also a role in T- cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade. Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Also functions downstream of receptors mediating cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Plays also a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity). Key=storage, value=Store at 4°C for up to 6 months. Key=custom_attribute_1, value=SYK Key=custom_attribute_2, value=Phospho-Tyr348 Key=options Key=media_gallery Key=extension_attributes Key=tier_price Key=tier_price_changed Key=category_ids Key=quantity_and_stock_status Key=is_salable Key=website_ids Key=request_path Key=rating_summary Key=_cache_instance_store_filter Key=media_gallery_images
The SYK (Phospho-Tyr348) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor SYK (Phospho-Tyr348) protein expression profile in cells. The kit can be used for measuring the relative amounts of SYK (Phospho-Tyr348) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on SYK (Phospho-Tyr348).
1 kit, containing two 96-well plates and all necessary reagents
Description
The SYK (Phospho-Tyr348) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor SYK (Phospho-Tyr348) protein expression profile in cells. The kit can be used for measuring the relative amounts of SYK (Phospho-Tyr348) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on SYK (Phospho-Tyr348).
Storage & Handling
Store at 4°C for up to 6 months.
Cite This Product
SYK (Phospho-Tyr348) Colorimetric Cell-Based ELISA Kit (Boster Biological Technology, Pleasanton CA, USA, Catalog # EKC2005)
*if product is indicated to react with multiple species, protein info is based on the gene entry specified above in "species".
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