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- Table of Contents
1 Citations
Facts about Alpha-synuclein.
Reduces neuronal responsiveness to various apoptotic stimuli, resulting in a decreased caspase-3 activation. .
Human | |
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Gene Name: | SNCA |
Uniprot: | P37840 |
Entrez: | 6622 |
Belongs to: |
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synuclein family |
alpha-Synuclein; Lewy body) 4; MGC110988; NACP; non A-beta component of AD amyloid; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; non-A4 component of amyloid; PARK1; PARK4; SNCA; synuclein, alpha (non A4 component of amyloid precursor); Synuclein-alpha
Mass (kDA):
14.46 kDA
Human | |
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Location: | 4q22.1 |
Sequence: | 4; NC_000004.12 (89724099..89838324, complement) |
Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.
Cytoplasm. Membrane. Nucleus. Cell junction, synapse. Secreted. Membrane-bound in dopaminergic neurons.
PMID: 8248242 by Ueda K., et al. Molecular cloning of cDNA encoding an unrecognized component of amyloid in Alzheimer disease.
PMID: 7601450 by Campion D., et al. The NACP/synuclein gene: chromosomal assignment and screening for alterations in Alzheimer disease.
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