Recombinant Human CNTF Protein

CNTF protein, Human

Ciliary Neurotrophic Factor (CNTF) is a cytokine belonging to the Interleukin 6 (IL-6) family, which also includes IL-6, Oncostatin M, Leukemia Inhibitory Factor (LIF), and Cardiotrophin-1. Structurally, CNTF resembles a four-helix bundle composition, similar to the other members of the IL-6 family. The receptor for CNTF is composed of three parts: a gp130-like subunit common in the IL-6 receptor family, a LIF Receptor β subunit, and a CNTF specific α receptor subunit. Upon binding to the CNTF, the β subunit of the CNTF receptorwill undergo tyrosine phosphorylation, and activate the intracellular JAK/STAT pathway. The main function of CNTF in vivo is to promote the differentiation and survival of a variety of neurons and glial cells, including sympathetic precursor cells and spinal motor neurons. Recombinant human Ciliary Neurotrophic Factor (rhCNTF) produced in E. coli is a single non-glycosylated polypeptide chain containing 199 amino acids. A fully biologically active molecule, rhCNTF has a molecular mass of 22.8 kDa analyzed by reducing SDS-PAGE.

Product Info Summary

SKU: R00609
Size: 100μg/vial
Origin Species: Human
Source: E. coli His12-Met200

Product Name

Recombinant Human CNTF Protein

View all CNTF recombinant proteins

SKU/Catalog Number

R00609

Size

100μg/vial

Description

Ciliary Neurotrophic Factor (CNTF) is a cytokine belonging to the Interleukin 6 (IL-6) family, which also includes IL-6, Oncostatin M, Leukemia Inhibitory Factor (LIF), and Cardiotrophin-1. Structurally, CNTF resembles a four-helix bundle composition, similar to the other members of the IL-6 family. The receptor for CNTF is composed of three parts: a gp130-like subunit common in the IL-6 receptor family, a LIF Receptor β subunit, and a CNTF specific α receptor subunit. Upon binding to the CNTF, the β subunit of the CNTF receptorwill undergo tyrosine phosphorylation, and activate the intracellular JAK/STAT pathway. The main function of CNTF in vivo is to promote the differentiation and survival of a variety of neurons and glial cells, including sympathetic precursor cells and spinal motor neurons. Recombinant human Ciliary Neurotrophic Factor (rhCNTF) produced in E. coli is a single non-glycosylated polypeptide chain containing 199 amino acids. A fully biologically active molecule, rhCNTF has a molecular mass of 22.8 kDa analyzed by reducing SDS-PAGE.

Storage & Handling

Lyophilized recombinant human Ciliary Neurotrophic Factor (rhCNTF)remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhCNTF remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.

Cite This Product

Recombinant Human CNTF Protein (Boster Biological Technology, Pleasanton CA, USA, Catalog # R00609)

Form

Lyophilized

Formulation

Lyophilized after extensive dialysis against PBS.

Purity

>95%, by SDS-PAGE quantitative densitometry by Coomassie® Blue Staining.

Predicted MW

21.7KD

Endotoxin

Less than 1 EU/μg of rhCNTF as determined by LAL method.

Amino Acid Sequence

HRRDL CSRSI WLARK IRSDL TALTE SYVKH QGLNK NINLD SADGM PVAST DQWSE LTEAE RLQEN LQAYR TFHVL LARLL EDQQV HFTPT EGDFH QAIHT LLLQV AAFAY QIEEL MILLE YKIPR NEADG MPINV GDGGL FEKKL WGLKV LQELS QWTVR SIHDL RFISS HQTGI PARGS HYIAN NKKM

Validation Images & Assay Conditions

Gene/Protein Information For CNTF (Source: Uniprot.org, NCBI)

Gene Name

CNTF

Full Name

Ciliary neurotrophic factor

Weight

21.7KD

Superfamily

CNTF family

Alternative Names

ciliary neurotrophic factor; CNTF; HCNTF CNTF HCNTF ciliary neurotrophic factor ciliary neurotrophic factor|Ciliary Neuronotrophic Factor

*If product is indicated to react with multiple species, protein information is based on the gene entry specified above in "Species".

For more info on CNTF, check out the CNTF Infographic

CNTF infographic

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In this infographic, you will see the following information for CNTF: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact us at [email protected].

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