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Keywords: Neuroscience 2019, McCormick, Chicago, Scientists, World, Pathway, Posters, Technical Resource, Free Phone Accessories, Dr. Booster Plush Doll

Neuroscience 2019 is taking place October 19-23 at McCormick Place in Chicago. Join 30,000 scientists from around the world to discover hot topics and tools for neuroscience.

Stop by Boster’s Booth #1805 and pick up some pathway posters, technical resources, free phone accessories, and your very own Dr. Booster plush doll.

Keywords: Antibody, Validated for Human, Cross-reactivity, Rat, Primary Antibodies, Technical Blog

Choosing the right antibody can get complicated, so it’s not surprising that customers frequently ask us questions like, “If this antibody is validated for human, will it cross-react with rat, too?” In this technical blog, we review the concept of cross-reactivity, go through the basic steps for determining antibody cross-reactivity, and provide an example.

Keywords: Breast cancer, October, Global, Organizations, Education and Research, Breast Cancer Awareness Month, Cancer, Death, American Women, Worldwide, Cancer, Women

October is Breast Cancer Awareness Month, a global annual campaign that unites organizations around the world to raise awareness for breast cancer, and highlights the importance of breast cancer education and research.

Breast cancer is the second leading cause of cancer death in American women. About 12%, or 1 in 8, women in the US will develop breast cancer over the course of her lifetime. Worldwide, breast cancer is the most common cancer in women.

Keywords: Project Manager, Timeline, Rabbit polyclonals, Mouse monoclonals, Rabbit monoclonals, Custom Antibody Services

Our team of experts is dedicated to provide services that are tailored to your needs and specifications. We are committed to being transparent about the timeline, the costs involved, and the progress of your project. A project manager will be assigned to your project to answer all your questions.

Keywords: Antigens, Tumor Cells, T-cells, Apoptosis, Cancer Cells, PD-1, Programmed Cell Death-1, PD-L1, PD-L2, Chronic Autoimmune Inflammation

In normal conditions, mutated antigens from tumor cells will lead to the activation of T cells that bind to and trigger apoptosis in target cancer cells. On the surface of T cells are PD-1 (programmed cell death-1) receptors whose ligands include PD-L1 and PD-L2.

Together, PD-1 and PD-L1/PD-L2 are involved with inhibiting T cell response so that the immune response is only initiated when necessary, avoiding chronic autoimmune inflammation.

Keywords: NIH Research Festival, Life Science Exhibits, Houston Marriott, Texas Medical Center, Bethesda Campus

Boster will be attending 2 exciting events and we hope to see you there!

The NIH Research Festival is happening this week from September 11-13 at the Bethesda Campus. Meet us at Booth# 607 and pick up some great Boster gifts!

The Life Science Exhibits will be held next Thursday, September 19, at Houston Marriott at the Texas Medical Center. If you’re attending the exhibit, drop by to say hi!

Keywords: World Alzheimer's Month, WHO, Dementia, Stigma, Alzheimer’s Disease, Antibodies, APP, Amyloid beta, APOE, Presenilin, Tau

September is World Alzheimer’s Month, an international campaign to raise dementia awareness and challenge stigma, and the purple ribbon is the chosen color to represent awareness for Alzheimer’s disease.

According to WHO, over 50 million people worldwide have dementia. As the most common form of dementia, Alzheimer’s disease contributes to 60-70% cases of dementia. Alzheimer’s disease is characterized by an irreversible decline in cognitive and behavioral abilities that will eventually render the person completely reliant on others for basic activities in daily life.

Keywords: ELISA, Protein, PicoKine™ ELISA Kits

To set up a standard curve, ELISA standards should be carefully prepared for accurate sample quantification of the target protein. We’ve provided some guidelines for you to consider when preparing ELISA standards.

Keywords: Rabbit Monoclonal Antibodies, Flow Cytometry, IP, IF, IHC, ICC, WB, ELISA, Immune, Phospho-peptides, Carbohydrates, Immunogens, Immunogenic, Mouse

Boster now offers 1300+ rabbit monoclonal antibodies validated for many applications including flow cytometry, IP, IF, IHC, ICC, WB, and ELISA. The rabbit immune system has historically been useful for generating a larger diversity of high affinity antibodies, including phospho-peptides, carbohydrates, and immunogens not immunogenic in mouse. Search our catalog for your gene target today, and get better results with Boster!

Keywords: CTL4, Cytotoxic T-lymphocyte–associated Antigen, CD152, Protein, Immunoglobin, T-cell, TCR, CD28, Membrane

CTLA4 (cytotoxic T-lymphocyte–associated antigen 4, aka CD152) is a transmembrane protein member of the immunoglobin superfamily. This protein receptor plays a key role in downregulating immune responses (e.g., inhibit T-cell activation).

Its expression relies on the stimulation of TCR and the binding between CD28 and B7 (B7-1/CD80 & B7-2/CD86), which both promote T-cell activation. Stimulating signals from TCR and CD28-B7 binding release CTLA4 from vesicles and translocates CTLA4 to the cell membrane where CTLA4 undergoes dimerization.

Keywords: Research, Antibodies, Custom Antibody, Zebrafish, Drosophila, C. Elegans, Yeast, Mammalian, Custom Rabbit Polyclonal Antibodies

To best serve the research communities where suitable antibodies are hard to find, Boster provides a special discounted custom antibody production service for researchers who use non-mammalian models such as Zebrafish, Drosophila, C. elegans, and Yeast.

Keywords: IHC, ICC, Tissue, Morphology, Antigenicity, Cells, Antigen, Immobilization

Sample fixation is a crucial step for every successful IHC/ICC experiment. During the tissue preparation process, appropriate sample fixation can help preserve morphology, prevent tissue degradation, ensure antigenicity, and protect cells from damage.

Since different types of fixatives have varying properties, choosing which fixing solution to use will depend on your sample type and antigen. We recommend testing to determine which specific type of fixative will be most effective for antigen immobilization in your sample.

July 26
2019

Keywords: Hepatitis B, Hepatitis C, World Hepatitis Day, WHO, Disease, World Hepatitis Alliance, HHS, CDC, Cancer, Viruses, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Tuberculosis

This upcoming Sunday, July 28th, is World Hepatitis Day, an annual international awareness event for 325 million people globally affected by hepatitis. World Hepatitis Day is one of WHO's four disease-specific global health days that is supported by organizations such as the World Hepatitis Alliance, HHS, and CDC.

Keywords: Immune Receptors, Toll-like Receptors, Intracellular Compartments, Endosome, TLRs, Pathogen, Molecular, Patterns, PAMPs, DAMPs, Immunity

Toll-like receptors (TLRs) are immune receptors localized to the cell surface or intracellular compartments like the endosome. TLRs’ ability to recognize pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) make them key players in innate immunity.

Keywords: Multiplex ELISA, Quansys Biosciences, Q-Plex™, 96-Well Plate, Biomaker, Reagents

We've partnered with Quansys Biosciences to provide Q-Plex™ Multiplex ELISA kits that allow for concurrent measurement of multiple biomarkers. Each kit contains a 96-well plate of the relevant biomarker panel and includes all required reagents to perform testing. Using just 50 µl of sample per well, up to 80 samples can be assayed for all markers in the panel within 2.5 hours.

Keywords: Multiplex ELISA, Quansys Biosciences, Q-Plex™, 96-Well Plate, Biomaker, Reagents

Boster has partnered with Quansys Biosciences to provide Q-Plex™ Multiplex ELISA kits that allow for concurrent measurement of multiple biomarkers. Each kit contains a 96-well plate of the relevant biomarker panel and includes all required reagents to perform testing. Using just 50 µl of sample per well, up to 80 samples can be assayed for all markers in the panel within 2.5 hours.

Keywords: Glutamine, Metabolism, Pathway, Proliferating Cells, Cancer Cells, Protein, Glutaminolysis, ELISAAmino Acid, ASCT2, SLC1A5

As the most abundant free amino acid in the plasma, glutamine participates in a variety of biochemical processes, such as protein and lipid synthesis, cellular energy production, and nitrogen and carbon donation.

Glutamine metabolism occurs in proliferating cells, particularly cancer cells. The process begins with glutamine entering the cell through the amino acid transporter ASCT2/SLC1A5. In the mitochondria, glutamine undergoes glutaminolysis, which includes reaction steps from the citrate cycle and the malate-aspartate shuttle.

Keywords: ELISA, Peptides, Proteins, Antibodies, Hormones, Immunoassays

ELISA is a convenient and simple method to quantitatively or qualitatively detect peptides, proteins, antibodies, and hormones in samples, rendering it as one of the most widely used immunoassays.

Despite the many advantages of conducting ELISA, there are some mistakes that could turn your ELISA experiment sour. Help prevent this situation from happening by avoiding 5 common pitfalls when performing an ELISA.

Keywords: CD40, Signaling Pathway, TNFR, NF-κB, MAPK, Jak3/STAT3, PI3K/Akt, Pathways, Fibroblasts, B cells, Macrophages, Dendritic Cells

CD40, a costimulatory protein member of the TNFR superfamily, has been identified to regulate a broad range of cellular responses, including proliferation, differentiation, and cell death. CD40 can be found on several cell types, such as B cells, macrophages, dendritic cells, and fibroblasts, demonstrating its critical role in immune response and host defense. The binding of CD40L to CD40 stimulates APCs and leads to a number of downstream effects. Different gene expression patterns are activated by CD40 for certain cell types. In addition, several pathways are triggered through CD40 signal transduction. Examples include the NF-κB, MAPK, Jak3/STAT3, and PI3K/Akt pathways.

Keywords: PicoKine™ ELISA, ELISA Kit, Promotion, BOGO ELISA, Inflammatory Cytokines, Insulin, Discount

Last month to buy 1 PicoKine™ ELISA kit and get the second same PicoKine™ ELISA kit for FREE! This promotion is for inflammatory cytokines and insulin ELISA kits. Redeem your BOGO ELISA promotion soon before it ends on May 31st.

Keywords: San Diego Convention Center, American Association of Immunologists, AAI 2019, Annual Meeting, Pathway, Posters, Boster Plush Doll, Technical Resources, Free Phone Accessories

Join us at the San Diego Convention Center from May 9-13 for the American Association of Immunologists (AAI) 2019 Annual Meeting.

Be sure to stop by Boster Bio’s Booth #1301 and pick up some pathway posters, technical resources, free phone accessories, and your very own Dr. Booster plush doll. See you soon!

Keywords: Cellular Autofluorescence, NADPH, Collagen, Elastin, Fluorochromes FITC, GFP, Pacific Blue, Fluorescence

Cellular autofluorescence is a common problem for all fluorescence-based cell detection methods. The cells’ natural fluorescence is caused by the presence of various biological structures such as collagen, elastin, NADPH, etc., which interferes with analysis by reducing signal sensitivity and resolution of fluorochromes like FITC, GFP, and Pacific Blue.

Keywords: Caspase Cascade, Pathway, cysteine Proteases, Apoptosis, Mitochondria, Proteolysis, Cell Disassembly, Neurodegenerative Disorders, Parkinson’s Disease, Alzheimer’s Disease, Tumorigenesis, Autoimmune Disorders

Caspases are a family of cysteine proteases that respond in succession when activated by apoptosis stimuli, leading to proteolysis, cell disassembly, and apoptosis. The caspase cascade can be triggered by stimuli from the cell surface or the mitochondria.

Keywords: Happy Easter, 2019, Antibodies, ELISA Kit, Buy One Get One, Recombinant Proteins, WB, IHC, Flow Cytometry, Quality Guarantee

Celebrate this Easter with a heart full of love, peace, and cheer. Have a blessed and wonderful Easter from all of us at Boster!

Keywords: ELISA Kit, Immunoassays, Assay, Antibodies, Peptides, Proteins, Hormones

The ELISA (enzyme-linked immunosorbent assay) is recognized by scientists for its many advantages. The assay is convenient, quick, and simple to execute. ELISA’s versatility to detect peptides, proteins, antibodies, and hormones, and its ability to generate quantitative and qualitative data make it one of the most popular and powerful immunoassays available.

Keywords: Research, Antibodies, Special Discount, Custom Antibody, Non-Mammalian, Zebrafish, Drosophila, C Eelegans, Yeast

To best serve the research communities where suitable antibodies are hard to find, Boster provides a special discounted custom antibody production service for researchers who use non-mammalian models such as Zebrafish, Drosophila, C. elegans, and Yeast.

Keywords: PicoKine™ ELISA, Promotion, Insulin, Inflammatory Cytokines, Buy 1 Get 1 Free

From now until May 31st, you can buy 1 PicoKine™ ELISA kit and get the second same PicoKine™ ELISA kit for FREE. This promotion is for inflammatory cytokines and insulin ELISA kits.

Click “Claim your discount” to learn more details about the promotion and browse the eligible products to find your ELISA kit.

Keywords: AACR 2019, Annual Meeting, Atlanta, Georgia, Pathway, Posters, Gifts, Technical Resources, Free Phone Accessories, Experimental Biology, Orlando, Florida

Boster will be attending 2 exciting events and we hope to see you there!

The AACR 2019 Annual Meeting in Atlanta, Georgia is coming up this weekend from March 29th – April 3rd. Meet us at Booth#4627 and pick up some great Boster gifts!

Keywords: Research Spotlight, March, 2019, Lung Cancer, Alchoholi Liver Disease, Stroke, Emphysema, Schizophrenia, Nasopharynx Cancer

The March edition of Research Spotlight features 10 recent research discoveries from scientists whom Boster has served.

Scientists of this month’s selected research publications investigated several diseases and disorders, such as lung cancer, nasopharynx cancer, alcoholic liver disease, stroke, emphysema, and schizophrenia.

Keywords: PicoKine™ ELISA, Buy One & Get One, Promotion, Discount, FREE, Inflammatory Cytokines, Insulin

From now until May 31st, you can buy 1 PicoKine™ ELISA kit and get the second same PicoKine™ ELISA kit for FREE. This promotion is for inflammatory cytokines and insulin ELISA kits.

Mar 06
2019

Keywords: T cells, Lymphocytes, TCR, Cell Surface, Cytotoxic T cells, Antigen Presenting Cells (APC), Major Histocompatibility Complex (MHC)

T cells are a category of lymphocytes that differ from other lymphocytes because of the unique T cell receptor (TCR) present on the cell surface. Together with co-receptors (CD4 for helper T cells and CD8 for cytotoxic T cells), the TCR enables T cells to detect and react to peptide antigens, which are pathogens digested by antigen presenting cells (APCs) and displayed on major histocompatibility complex (MHC) molecules.

Keywords: Western BLotting, Sience Research, Research, Band Size

First described in 1979, the technique of western blotting has since become one of the most commonly used analytical methods in life science research. Just last week, we received a few questions from confused researchers about weird band sizes in their western blot results

Keywords: 25 Years, Experience, Boster, Signal, ELISA, PicoKine ELISA, Antigen, Consistency, Cross-reactivity

With 25+ years of experience, Boster provides PicoKine™ ELISA kits powered by proprietary signal-enhancing blocking technology. These ELISA kits can detect antigens in the pg/ml range with low background. We thoroughly validate each lot to ensure lot-to-lot consistency, reproducibility, and cross-reactivity.

Keywords: February, Research Spotlight, Features, Glioblastoma, Cancer, Pancreatic Carcinoma, Osteosarcoma, Hepatocellular Carsicoma, Publications, Diabetes Mellitus

Our February edition of Research Spotlight features 10 recent research discoveries from scientists whom Boster has served.

This month’s selected research publications investigate targets related to a number of cancers, such as osteosarcoma, hepatocellular carcinoma, pancreatic carcinoma, and glioblastoma, and also include studies that examine targets of Parkinson’s disease and type 2 diabetes mellitus.

Keywords: World Cancer Day, American Cancer Society, Smoking, Treatment, Organization, February 4

Today is World Cancer Day. Each year, organizations and people from around the world unite on February 4th to raise awareness about cancer.

According to the American Cancer Society, cancer mortality had dropped 27% from 1991 to 2016. This decline is mostly attributed to decreases in smoking and advancements in early cancer detection and treatment.

Keywords: Amino Acid, Plasma, Glutamine Metabolism, Pathway, Cancer Cells, Transporter, Glutaminolysis, Lipid Systhesis, Cellular Energy

As the most abundant free amino acid in the plasma, glutamine participates in a variety of biochemical processes, such as protein and lipid synthesis, cellular energy production, and nitrogen and carbon donation.

Glutamine metabolism occurs in proliferating cells, particularly cancer cells. The process begins with glutamine entering the cell through the amino acid transporter ASCT2/SLC1A5. In the mitochondria, glutamine undergoes glutaminolysis, which includes reaction steps from the citrate cycle and the malate-aspartate shuttle.

Keywords: Lab, Research, IHC, Antibody, Signal

In the lab, researchers invest time and effort to optimize the sample preparation and sample staining processes of IHC. When successful, the results produce a strong and specific signal.

However, how do we know the results have been interpreted correctly?

Currently, there are 6 established IHC controls that will help you determine the specificity of the observed antibody staining.

Keywords: January, Research Spotlight, Boster, MAPK, Wnt, β-catenin, TGF-β1, Smad3, NF-κB, Akt, mTOR, AMPK, ULK1, Pathway

The January edition of Research Spotlight features 10 recent research discoveries from scientists whom Boster has served.

Scientists of this month’s selected research publications investigate various aspects of several pathways such as the MAPK, Wnt/β-catenin, TGF-β1/Smad3, NF-κB, Akt/mTOR, and AMPK/ULK1 signaling pathways.

Keywords: Boster, Guarantee, Quality, Scientific Expert, Products, Datasheet, Free replacement

When you choose Boster, we guarantee product quality and timely support from our scientific experts. Our products are guaranteed to meet specifications on the datasheets. If the product does not work as stated, we will provide a refund or free replacement.

Keywords: 2019, New Year, Search, Boster, Goals, Lab

Happy New Year! As we begin 2019, what are your top goals for your lab in the new year? Try the word search below to see what you care most about this year.

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