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- Table of Contents
, No Gclids
Usherin Antibodies
AND USH2A ELISA kits, Usherin Proteins
Many biological assays use antibodies to detect Usherin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Usherin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Usherin antibodies...
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USH2A Infographic by Boster Bio
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USH2A Overview
Facts about Usherin.
Usherin (USH2A)
Involved in vision and hearing. .
Gene Information
| Human | |
|---|---|
| Gene Name: | USH2A |
| Uniprot: | O75445 |
| Entrez: | 7399 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Usherin
Molecular Weight
Mass (kDA):
575.6 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q41 |
| Sequence: | 1; NC_000001.11 (215622891..216423448, complement) |
Tissue Specificity
Present in the basement membrane of many, but not all tissues. Expressed in retina, cochlea, small and large intestine, pancreas, bladder, prostate, esophagus, trachea, thymus, salivary glands, placenta, ovary, fallopian tube, uterus and testis. Absent in many other tissues such as heart, lung, liver, kidney and brain. In the retina, it is present in the basement membranes in the Bruch's layer choroid capillary basement membranes, where it localizes just beneath the retinal pigment epithelial cells (at protein level). Weakly expressed. Isoform 2 is expressed in fetal eye, cochlea and heart, and at very low level in brain, CNS, intestine, skeleton, tongue, kidney and lung. Isoform 2 is not expressed in stomach and liver. In adult tissues, isoform 2 is expressed in neural retina and testis, and at low level in brain, heart, kidney and liver. Isoform 1 displays a similar pattern of expression but is expressed at very low level in fetal cochlea.
Subcellular Localizations
Cell projection, stereocilium membrane; Single-pass type I membrane protein. Component of the interstereocilia ankle links in the inner ear sensory cells. In photoreceptors, localizes at a plasma membrane microdomain in the apical inner segment taht surrounds the connecting cilia called periciliary membrane complex.; [Isoform 2]: Secreted.
PTMs
- Disulfide bond
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/USH2A
bosterbio.com/bosterbio-gene-info-cards/USH2A
References
PMID: 9624053 by Eudy J.D., et al. Mutation of a gene encoding a protein with extracellular matrix motifs in Usher syndrome type IIa.
PMID: 10729113 by Weston M.D., et al. Genomic structure and identification of novel mutations in usherin, the gene responsible for Usher syndrome type IIa.