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- Table of Contents
Facts about Forkhead box protein E1.
Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression.
Human | |
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Gene Name: | FOXE1 |
Uniprot: | O00358 |
Entrez: | 2304 |
Belongs to: |
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No superfamily |
FKHL15HFKL5; forkhead box E1 (thyroid transcription factor 2); forkhead box E2; Forkhead box protein E2; forkhead, drosophila, homolog-like 15; Forkhead-related protein FKHL15; HFKH4Thyroid transcription factor 2; TITF2HNF-3/fork head-like protein 5; TTF2forkhead box protein E1; TTF-2FOXE2
Mass (kDA):
38.076 kDA
Human | |
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Location: | 9q22.33 |
Sequence: | 9; NC_000009.12 (97853226..97856717) |
Detected in adult brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, heart, colon, small intestine testis and thymus. Expression was strongest in heart and pancreas.
Nucleus.
If you're interested in finding the best antibody for this gene, read Boster Bio: Best Uses of the FOXE1 Marker. This biographical piece describes Steven Boster, his antibodies, and his company. The FOXE1 marker is the best available antibody to detect this gene in mouse models. The antibody provides high-affinity binding to human cells. Moreover, it is validated by Western blotting, immunohistochemistry, and ELISA assays.
The results of His research on the FOXE1 marker are compelling. The gene's occurrence in thyroid cancer is consistent with other findings in genetic studies. However, despite the positive correlation, FOXE1 mutations are not specific to thyroid cancer. There are many other genes and SNPs that might explain this association. The study results of one such researcher have already been published. These are the first publications to demonstrate a genetic link between FOXE1 mutations and thyroid cancer.
The best uses of the FOXE1 marker involve its ability to detect direct differentiation in cells. This marker is found on a variety of cell types, from normal to cancerous. The anti-rFoxE1 antibody was a gift from R. Di Lauro. Using the same primers as anti-rFoxA1, anti-rFoxE1 antibody was used to detect the target protein.
PMID: 9052737 by Wiese S., et al. The novel human HNF-3/fork head-like 5 gene: chromosomal localization and expression pattern.
PMID: 9169137 by Chadwick B.P., et al. FKHL15, a new human member of the forkhead gene family located on chromosome 9q22.