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- Table of Contents
Facts about Multidrug resistance-associated protein 9.
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Human | |
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Gene Name: | ABCC12 |
Uniprot: | Q96J65 |
Entrez: | 94160 |
Belongs to: |
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ABC transporter superfamily |
ATP-binding cassette transporter sub-family C member 12; ATP-binding cassette, sub-family C (CFTR/MRP), member 12; MGC27071; MRP9ATP-binding cassette sub-family C member 12; multidrug resistance-associated protein 9
Mass (kDA):
152.297 kDA
Human | |
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Location: | 16q12.1 |
Sequence: | 16; NC_000016.10 (48082973..48146770, complement) |
Expressed in testis (at protein level). Widely expressed at low level. Isoform 5 is specifically expressed in brain, testis and breast cancer cells.
Membrane; Multi-pass membrane protein.
You have found the right place if you are looking for a review of the ABCC12 marker. The information here covers the ABCC12 Marker, the Anti-ABCC12 Marker, and Boster Bio: Best Uses of The ABCC12 Marker. It also covers gene infographics and the benefits of ABCC12Marker. This article covers Boster Bio's Best Uses of the ABCC12 Marker in Gene Infographics
The ABCC12 genetic member is a member in the ABCB11 superfamily. It is expressed primarily in the liver and is a candidate marker for hepatocellular carcinoma. The development of hepatitis C is also associated to this gene. This is a type if liver cancer that affects young children. Although it cannot predict the onset of hepatocellular cancer, this marker can improve the prognosis and survival rates of children who have been affected by the mutation.
The ABCC12 gene may be a biomarker for breast carcinoma. Studies have shown that ABCC gene expression is linked to the presence of ER and PR. This marker could be useful in guiding treatment. The ABCC genes is a carrier of lipids. It also contains amino acids, steroids, and chemical substances, including chemotherapy drugs. High ABCC gene expression is associated with resistance to chemotherapy. Understanding the role of the ABCC gene in BC can help improve treatment options for patients.
PMID: 11688999 by Yabuuchi H., et al. Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12.
PMID: 11483364 by Tammur J., et al. Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12.