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- Table of Contents
Facts about Zinc finger MIZ domain-containing protein 1.
The stimulation of AR action is dependent upon sumoylation (PubMed:14609956, PubMed:26522984). Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC.
Human | |
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Gene Name: | ZMIZ1 |
Uniprot: | Q9ULJ6 |
Entrez: | 57178 |
Belongs to: |
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No superfamily |
FLJ13541; hZIMP10; KIAA1224; KIAA1224Zimp10; MIZ; PIAS-like protein Zimp10; RAI17; RAI17TRAFIP10; retinoic acid induced 17; Retinoic acid-induced protein 17; RP11-519K18.1; TRAFIP10; Zimp10; ZIMP10FLJ00092 protein; zinc finger MIZ domain-containing protein 1; zinc finger, MIZ-type containing 1; zinc finger-containing, Miz1, PIAS-like protein on chromosome 10; ZMIZ1
Mass (kDA):
115.483 kDA
Human | |
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Location: | 10q22.3 |
Sequence: | 10; NC_000010.11 (79068966..79316519) |
Expressed most abundantly in ovary and, at lower levels, in prostate, spleen and testis. Weak expression, if any, in thymus, small intestine, colon and peripheral blood leukocytes.
Nucleus, nucleoplasm. Cytoplasm. Enriched at replication foci throughout S phase.
PMID: 14609956 by Sharma M., et al. hZimp10 is an androgen receptor co-activator and forms a complex with SUMO-1 at replication foci.
PMID: 26522984 by Pinnell N., et al. The PIAS-like coactivator Zmiz1 is a direct and selective cofactor of Notch1 in T cell development and leukemia.