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Zbtb7b Antibodies
AND Zbtb7b ELISA kits, Zbtb7b Proteins
Many biological assays use antibodies to detect Zbtb7b, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Zbtb7b in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Zbtb7b antibodies...
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Zbtb7b Overview
Facts about Zinc finger and BTB domain-containing protein 7B.
Zinc finger and BTB domain-containing protein 7B (Zbtb7b)
Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells at a tissue-specific way (PubMed:15729333, PubMed:29420538).
Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T- cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Zbtb7b |
| Uniprot: | Q64321 |
| Entrez: | 22724 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
c-Krox; hcKroxc-Krox; Krueppel-related zinc finger protein cKrox; kruppel-related zinc finger protein hcKrox; T-helper-inducing POZ/Krueppel-like factor; ThPOK; Th-POK; ZBTB15; ZBTB15zinc finger protein 67 homolog (mouse); ZBTB7B; ZFP67; zfp-67; zinc finger and BTB domain containing 15; zinc finger and BTB domain containing 7B; Zinc finger and BTB domain-containing protein 15; zinc finger and BTB domain-containing protein 7B; Zinc finger protein 67 homolog; Zinc finger protein 857B; Zinc finger protein Th-POK; ZNF857B; ZNF857BDKFZp686G01254
Molecular Weight
Mass (kDA):
58.918 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 3 F1|3 39.09 cM |
| Sequence: | 3; |
Tissue Specificity
Widely expressed, with a higher level in skin. Expressed in thymus. Restricted to CD4 cells (mature single positive CD4(+) and intermediate CD4(+)CD8(+) cells). Expressed in the luminal epithelial cells in the mammary glands where is up- regulated at late pregnancy and lactation (PubMed:29420538). Expression is enriched in brown fat (PubMed:28784777).
Diseases
- Scleroderma
- Lymphoma
- Localized Scleroderma
- Noonan Syndrome
- Epithelioma
- Peripheral T-cell Lymphoma
- Thymoma
- Pre-eclampsia
- Tissue Adhesions
- Fetal Growth Retardation
- Diffuse Scleroderma
- Sex Chromosome Aberrations
- Immunologic Deficiency Syndromes
Pathways
- Cell Development
- Cell Differentiation
- Cell Adhesion
- T Cell Differentiation
- Cytokine Production
- Translation
- Dedifferentiation
PTMs
- Acetylation
- Deacetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Zbtb7b
bosterbio.com/bosterbio-gene-info-cards/Zbtb7b
References
PMID: 7937772 by Galera P., et al. c-Krox, a transcriptional regulator of type I collagen gene expression, is preferentially expressed in skin.
PMID: 15729333 by He X., et al. The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment.