Zinc finger and BTB domain-containing protein 18 (ZBTB18)

Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain growth. Plays a crucial role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis.

Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'- [AC]ACATCTG[GT][AC]-3' that contains the E box center, and functions by recruiting chromatin remodeling multiprotein complexes.