ZRANB3 Antibodies

AND ZRANB3 ELISA kits, ZRANB3 Proteins

Many biological assays use antibodies to detect ZRANB3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ZRANB3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ZRANB3 antibodies...

We validate the specificity of these antibodies to ZRANB3 by testing them on tissues known to express ZRANB3 positively and negatively. Browse below to find the ZRANB3 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: Septin9 Next: RAB6C

ZRANB3 Infographic by Boster Bio

All ZRANB3 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-ZRANB3 Antibody

Human, Mouse, Rat

$405
Cat # A08429
100ul

ZRANB3 Overview

Facts about DNA annealing helicase and endonuclease ZRANB3.

ZRANB3 3D structure. Source: alphafold

DNA annealing helicase and endonuclease ZRANB3 (ZRANB3)

DNA annealing helicase and endonuclease needed to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and restricting inappropriate recombination that could occur during template switching events (PubMed:21078962, PubMed:22704558, PubMed:22705370, PubMed:22759634, PubMed:26884333). Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an available 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase (PubMed:22759634).

In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity to be able to prevent disintegration of the replication fork and the formation of double-strand fractures (PubMed:22705370, PubMed:22704558). .

Gene Information

Human
Gene Name:	ZRANB3
Uniprot:	Q5FWF4
Entrez:	84083

Family

Belongs to:

SNF2/RAD54 helicase family

Alternative Names

MGC105033; MGC75012,4933425L19Rik; zinc finger Ran-binding domain-containing protein 3; zinc finger, RAN-binding domain containing 3

Molecular Weight

Mass (kDA):
123.248 kDA

Genomic Context


Human

Location:	2q21.3
Sequence:	2; NC_000002.12 (135164218..135531218, complement)

Subcellular Localizations

Nucleus. Chromosome. Following DNA damage, recruited to sites of DNA damage and stalled replication forks by polyubiquitinated PCNA (PubMed:22704558, PubMed:22705370, PubMed:22759634).