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- Table of Contents
Facts about Zinc finger protein ZPR1.
Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of mobile pre-mRNAs.
Human | |
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Gene Name: | ZPR1 |
Uniprot: | O75312 |
Entrez: | 8882 |
Belongs to: |
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ZPR1 family |
Zinc finger protein ZPR1
Mass (kDA):
50.925 kDA
Human | |
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Location: | 11q23.3 |
Sequence: | 11; NC_000011.10 (116773799..116789272, complement) |
Expressed in fibroblast; weakly expressed in fibroblast of spinal muscular atrophy (SMA) patients.
Nucleus. Nucleus, nucleolus. Nucleus, gem. Nucleus, Cajal body. Cytoplasm, perinuclear region. Cytoplasm. Cell projection, axon. Cell projection, growth cone. Colocalized with SMN1 in Gemini of coiled bodies (gems), Cajal bodies, axon and growth cones of neurons (By similarity). Localized predominantly in the cytoplasm in serum-starved cells growth arrested in G0 of the mitotic cell cycle. Localized both in the nucleus and cytoplasm at the G1 phase of the mitotic cell cycle. Accumulates in the subnuclear bodies during progression into the S phase of the mitotic cell cycle. Diffusely localized
PMID: 9852145 by Gangwani L., et al. Interaction of ZPR1 with translation elongation factor-1alpha in proliferating cells.
PMID: 8650580 by Galcheva-Gargova Z., et al. Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor.