ZP3 Antibodies

Zona pellucida sperm-binding protein 3 (ZP3)

The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of a few glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.

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Gene Information

Human
Gene Name:	ZP3
Uniprot:	P21754
Entrez:	7784

Family

Belongs to:
ZP domain family

Alternative Names

zona pellucida glycoprotein 3 (sperm receptor)

Molecular Weight

Mass (kDA):
47.018 kDA

Genomic Context

Human
Location:	7q11.23
Sequence:	7; NC_000007.14 (76397522..76442069)

Tissue Specificity

Oocytes.

Subcellular Localizations

[Processed zona pellucida sperm-binding protein 3]: Secreted, extracellular space, extracellular matrix. Located in oocyte zona pellucida.; Cell membrane; Single-pass type I membrane protein.

Diseases

• Infertility
• Autoimmune Reaction
• Tissue Adhesions
• Autoimmune Diseases
• Ovarian Diseases
• Female Infertility
• Pertussis
• Male Infertility
• Disorder Of Endocrine Ovary
• Diphtheria
• Cytomegalovirus Infections
• Inflammation

• Ovarian Failure, Premature
• Premature Menopause
• Autoimmunity
• Classical Galactosemia
• Embryonal Carcinoma
• Carcinoma

Interacting Proteins

• ACR

Pathways

• Fertilization
• Acrosome Reaction
• Exocytosis
• Oogenesis
• Glycosylation
• Secretion
• Localization
• Sperm-egg Recognition
• Oocyte Maturation
• Ovulation
• Immune Response
• Mating
• Oocyte Growth

• Translation
• Oocyte Development
• Pathogenesis
• Metaphase
• Sperm Capacitation
• Proteolysis
• Cortical Granule Exocytosis

PTMs

• Glycosylation
• Cleavage
• Deglycosylation
• Phosphorylation
• Biotinylation
• Reduction

• Amination
• Acetylation
• Methylation
• Ribosylation
• Ubiquitination
• Iodination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ZP3

Best Uses Of The ZP3 Marker

If you're looking for antibodies for Zona pelucida 3 (ZP3), you've come to the right place. Boster Bio provides high-affinity primary antibodies with excellent performance and validated against GnRH, a closely related protein in the body. Boster has high-affinity primary antibodies available for a variety of applications including immunohistochemistry, Western Blotting, and ELISA.

Zona pelucida 3 (ZP3)

The production of tag-free recombinant fusion protein encompassing the promiscuous T cell epitope of tetanus toxoid and dog zona pellucida glycoprotein-3 is a promising approach for feral cat population control. A study with rabbits revealed that antibodies against fZP (and pZP) were not effective in inhibiting in vitro fertilisation and sperm binding. However, antibodies to the fZP prevented in vitro fertilization and sperm-binding in cats.

The extracellular shell that surrounds an oocyte is called the human zona. It is vital for fertilization and oocyte development and serves as a target for immunocontraception. It is also called vitelline in non-mammals. It plays a crucial role in cross-breeding.

This multilayer glycoproteinspherical shell plays a crucial role in fertilization. The beginning of fertilization can be traced back to the interaction between spermatozoas and zona pellucida. Although it is assumed that the TP is purely elastic, it also contains dissipative powers. Spermatozoa that exhibit increased motility and repulsion to oocytes cannot penetrate this impenetrable barrier.

The ZP3 gene encodes a four hundred twenty-four amino acid long protein. It also contains a 22 aa-long signal peptide. It also contains an ortholog in the mouse genomic that encodes a pseudogene. The mouse ZP3 gene and the POM121 gene in rat are related. Although they share a similar structure, the mouse ZP3 gene does not have the 'ZP Domain'.

Heterologous sequence encoding ZP3 with nucleic acid

Heterologous is when a protein that was derived from another species or organism is inserted into a host cell. This is called "xenotransplantation". ZP3's heterologous nucleic acids sequence is found in humans as well as other species. It is an important component of neurotransmission and is involved in the regulation of brain function.

GnRH encoded in a sequence of heterologous nucleic amino acids

GnRH (gonadotrophin-releasing hormone), also known by luliberin or gonoliberin, plays an important role in the development of immature animals' reproductive systems. It is synthesized by the hypothalamus, diffuses into the portal system, and then passes from the anterior pituitary to the hypothalamus. GnRh2 stimulates LH/FSH secretion which is crucial for both males as well as female reproductive development. The function of GnRh2 is largely conserved throughout mammals, indicating that it is a key factor in animal reproduction.

The vaccine, Heterologous Nucleic A Sequence That Encodes GnRH In Boster Bio, is made using Fusogenic Peptides. These peptides disrupt endosomes and allow nucleic acids to bypass degradation. It can also targeted to specific cell groups for intracellular uptake. Homologous DNA recombination then incorporates the nucleic- acid into the host's DNA.

The nucleic Acid Sequence can also be directly administered to the body or introduced to the cells via viral vectors. There are many ways to introduce foreign genes into cells. These include cell fusion, chromosome-mediated gene transfer, and microcell-mediated gene transfer. Alternatively, fetal livers and autologous cells can also be used for gene delivery.

Furthermore, polynucleic substances containing the sequence immunocontraceptive molecule may be used as either contraceptives or expression vectors. These expression vectors are able to express heavy chains and light chains as well as antibodies. They are specifically designed to be effective in treating a wide range of diseases. They are useful for treating sexual dysfunction and can be used as a contraceptive.

Boster offers high-affinity prim antibodies

Boster Bio has developed a range of high-affinity antibodies that target the ZP3 marker for your next immunohistochemistry experiments. The antibodies have been validated in immunohistochemistry, Western blotting and ELISA. They can recognize this mark in a variety samples. This is the perfect antibody for your next immunohistochemistry study.

Immunoassays use primary antibodies as well as secondary antibodies. These techniques depend on the ability for antibodies to bind to antigens. Examples of immunoassays include Western Blotting, immunohistochemistry, and immunofluorescence, which are histopathology and proteomics tests. ELISA, which is an enzyme-linked immunesorbent assay, measures the presence of specific types of cells.

Boster Bio's primary antibody products are made from the immune system of host animals. Primarily, the antibodies are known as primary antibodies. They only bind to the targeted antibody. Because they only bind to the targeted antigen, their affinity is determined based on the non-covalent bonds they form. To test the specificity of primary antibodies, scientists immunize host animals with antigens. Once the antibody is recognized by the immune system, it is extracted from the animal’s sera and eggs.