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- Table of Contents
Facts about Mitogen-activated protein kinase kinase kinase 12.
May be an activator of the JNK/SAPK pathway. .
Human | |
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Gene Name: | MAP3K12 |
Uniprot: | Q12852 |
Entrez: | 7786 |
Belongs to: |
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protein kinase superfamily |
DLKEC 2.7.11.25; Dual leucine zipper bearing kinase; EC 2.7.11; Leucine-zipper protein kinase; MAPK-upstream kinase; MEKK12; mitogen-activated protein kinase kinase kinase 12; Mixed lineage kinase; MUKdual leucine zipper kinase DLK; protein kinase MUK; ZPKleucine zipper protein kinase; ZPKP1
Mass (kDA):
93.219 kDA
Human | |
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Location: | 12q13.13 |
Sequence: | 12; NC_000012.12 (53479669..53501205, complement) |
Highly expressed in brain and kidney.
Cytoplasm. Cell membrane. Behaves essentially as an integral membrane protein.
PMID: 8037767 by Reddy U.R., et al. Cloning of a novel putative protein kinase having a leucine zipper domain from human brain.
PMID: 14697235 by Itoh A., et al. SP3 acts as a positive regulator on the core promoter of human ZPK gene.