ZNF451 Antibodies

AND ZNF451 ELISA kits, ZNF451 Proteins

Many biological assays use antibodies to detect ZNF451, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ZNF451 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ZNF451 antibodies...

We validate the specificity of these antibodies to ZNF451 by testing them on tissues known to express ZNF451 positively and negatively. Browse below to find the ZNF451 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ZNF451 Infographic by Boster Bio

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ZNF451 (NM_001031623) Human Over-expression Lysate

Human

$960
Cat # LS026036
100 µg

ZNF451 Overview

Facts about E3 SUMO-protein ligase ZNF451.

ZNF451 3D structure. Source: alphafold

E3 SUMO-protein ligase ZNF451 (ZNF451)

E3 SUMO-protein ligase; has a taste for SUMO2 and SUMO3 and eases UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494). Plays a role in protein SUMO2 alteration in response to stress caused by DNA damage and by proteasome inhibitors (in vitro).

Required for MCM4 sumoylation (By similarity). Has no action with SUMO1 (PubMed:26524493).

Gene Information

Human
Gene Name:	ZNF451
Uniprot:	Q9Y4E5
Entrez:	26036

Family

Belongs to:

krueppel C2H2-type zinc-finger protein family

Alternative Names

FLJ90693; zinc finger protein 451

Molecular Weight

Mass (kDA):
121.484 kDA

Genomic Context


Human

Location:	6p12.1
Sequence:	6; NC_000006.12 (57088970..57170305)

Subcellular Localizations

Nucleus. Nucleus, PML body. Nucleus, nucleoplasm. Colocalizes with UBE2I/UBC9, SUMO1 and SUMO2 in nuclear granules; this probably requires sumoylation. Desumoylation leads to diffuse nucleoplasmic location.

Diseases

Inflammatory Disorder
Malignant Neoplasm Of Prostate
Malignant Neoplasms
Leukemia
Acute Promyelocytic Leukemia
Sarcoidosis

Interacting Proteins

UBE2I

PTMs

Sumoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ZNF451

References

PMID: 18656483 by Karvonen U., et al. ZNF451 is a novel PML body- and SUMO-associated transcriptional coregulator.

PMID: 24324267 by Feng Y., et al. Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-beta signaling.